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- W2562508360 abstract "Abstract The potential of many 18 F‐labeled (hetero)aromatics for applications in positron emission tomography remains underexplored because convenient procedures for their radiosynthesis are lacking. Consequently, simple methods to prepare radiofluorinated (hetero)arenes are highly sought after. Herein, we report the beneficial effect of primary and secondary alcohols on Cu‐mediated 18 F‐labeling. This observation contradicts the assumption that such alcohols are inappropriate solvents for aromatic fluorination. Therefore, we developed a protocol for rapid radiolabeling of an extraordinarily broad scope of boronic and stannyl substrates under general reaction conditions. Notably, radiofluorinated indoles, phenols, and anilines were synthesized directly from the corresponding unprotected precursors. Furthermore, the novel method enabled the preparation of radiofluorinated tryptophans, [ 18 F]F‐DPA, [ 18 F]DAA1106, 6‐[ 18 F]FDA, and 6‐[ 18 F]FDOPA." @default.
- W2562508360 created "2017-01-06" @default.
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- W2562508360 date "2017-01-18" @default.
- W2562508360 modified "2023-10-18" @default.
- W2562508360 title "Alcohol-Enhanced Cu-Mediated Radiofluorination" @default.
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- W2562508360 doi "https://doi.org/10.1002/chem.201604633" @default.
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