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• W2562563357 abstract "Abstract The F‐box protein FBXW 7 is the substrate‐recruiting subunit of an SCF ubiquitin ligase and a major tumor‐suppressor protein that is altered in several human malignancies. Loss of function of FBXW 7 results in the stabilization of numerous proteins that orchestrate cell proliferation and survival. Little is known about proteins that directly regulate the function of this protein. In the current work, we have mapped the interactome of the enigmatic pseudophosphatase STYX . We reasoned that a catalytically inactive phosphatase might have adopted novel mechanisms of action. The STYX interactome contained several F‐box proteins, including FBXW 7. We show that STYX binds to the F‐box domain of FBXW 7 and disables its recruitment into the SCF complex. Therefore, STYX acts as a direct inhibitor of FBXW 7, affecting the cellular levels of its substrates. Furthermore, we find that levels of STYX and FBXW 7 are anti‐correlated in breast cancer patients, which affects disease prognosis. We propose the STYX – FBXW 7 interaction as a promising drug target for future investigations." @default.
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• W2562563357 date "2016-12-22" @default.
• W2562563357 modified "2023-10-16" @default.
• W2562563357 title "The pseudophosphatase <scp>STYX</scp> targets the F‐box of <scp>FBXW</scp> 7 and inhibits <scp>SCF</scp> ^FBXW7 function" @default.
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• W2562563357 doi "https://doi.org/10.15252/embj.201694795" @default.
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• W2562563357 hasPublicationYear "2016" @default.
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