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• W2562570003 abstract "Airway epithelium presents a key role in asthma pathogenesis. A complex signaling involving suppressor of cytokine signaling protein family (SOCS), janus kinase (JAK) and signal transducer and activator of transcription (STAT) modulates asthma. Aerobic exercise (AE) reduces airway inflammation, but the role of SOCS-JAK-STAT mediating anti-inflammatory effects of exercise is unknown. Thus, 40 C57Bl/6 male mice were distributed in Control (Co), Exercise (Ex), Asthma (As) and Asthma+Exercise (As+Ex) groups. House dust mite (HDM - Dermatophagoides pteronyssinus; 100ug/mouse) was orotracheally administered once a week on days 0, 7, 14, 21, 28, 35 and 42. Low intensity treadmill aerobic training (1h/session, 5x/week, 4 weeks) was performed, beginning after the establishment of airway inflammation (day 17). Animals were euthanized on day 45. The results demonstrated that AE reduced HDM-increased total leukocytes (p" @default.
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• W2562570003 date "2015-09-01" @default.
• W2562570003 modified "2023-10-18" @default.
• W2562570003 title "Aerobic exercise reduces asthma phenotype through inhibition of SOCS-JAK-STAT signaling in airway epithelium" @default.
• W2562570003 doi "https://doi.org/10.1183/13993003.congress-2015.pa2211" @default.
• W2562570003 hasPublicationYear "2015" @default.
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