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- W2562655325 abstract "OBJECTIVE: To quantify and compare the volume of both temporal lobes (TL) and hippocampi in patients with TGA to a control group with magnetic resonance imaging (MRI). BACKGROUND: Impaired memory suggests involvement of TL and hippocampi of the brain in patients with TGA. Neuroimaging studies have documented quantitative changes in regional cerebral glucose, oxygen metabolism and cerebral blood flow in prior studies. There is no available report on volume of TL and hippocampi in patients with TGA. DESIGN/METHODS: This is a retrospective chart review of patients diagnosed with TGA who presented to Cleveland Clinic Florida during the 2009-2014 period and had work up completed with brain MRI. MRI images of these patients along with normal MRI images, matched for age, gender, and ethnicity were compared to quantify TL and hippocampal volume using Argus software. RESULTS: 28 subjects with a mean± standard deviation (mSD) age of 64.5±8.3 were included; 54[percnt] males and 46[percnt] females. The left and right TL mSD volume in milliliters (ml) in the TGA group were 65.08±6.79 and 67.26±6.9 respectively where as for control group were 63.4±4.38 and 65.1±6.47 respectively. The mSD difference between the left and right TL volume in ml in the TGA group was 4.03±3.34mL and for the control group it was 4.45±3.35mL. The left and right hippocampal mSD volume in ml in the TGA group were 2.66±0.45 and 2.78±0.51 mL respectively whereas for control group were 2.81 ±0.69 and 2.60±0.55 respectively. The mSD difference between the hippocampi volume in ml in TGA group was 0.23±0.2 mL and for the control group it was 0.33±0.28mL. CONCLUSIONS: While limited by study sample and retrospective analysis, our data suggests no statistically significant difference in TL (p≤0.1),hippocampi volume(p≤0.09), or TL lobe volume asymmetry (p≤0.3), although a trend was noted for hippocampal volume asymmetry(p≤0.07) compared to the control group. Disclosure: Dr. Boddepalli has nothing to disclose. Dr. Reyes has nothing to disclose. Dr. Salgado has received personal compensation in an editorial capacity from Belvoir Media Group. Dr. Candocia has nothing to disclose. Dr. Gandhi has nothing to disclose. Dr. Oppenheimer. has nothing to disclose." @default.
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- W2562655325 date "2015-04-06" @default.
- W2562655325 modified "2023-09-23" @default.
- W2562655325 title "The quantitative analysis of temporal lobes and Hippocampi in patients diagnosed with transient global amnesia (TGA). (P7.137)" @default.
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