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- W2562665623 abstract "Bacterial cell wall peptidoglycan (PGN), a polymer of disaccharide-pentapeptide repeating units is one of the most important molecular patterns recognised by innate immune receptors. Although the mechanism of action of PGNs leading to immunostimulation in the host is not yet completely understood, it has been shown that several families of innate immune receptors mediated PGN recognition such as the Toll-like receptors, NOD-like receptors and the recently discovered family of Peptidoglycan Recognition Proteins. Fragments of PGN and related small molecules can also elicit immune response [1]. Mannosylation of the monomeric unit of PGN (PGM) alters its effects on the immune system [2]. In particular, immunostimulating activity of mannosylated derivatives (ManPGM) [3] were decreased in comparison to the parent PGM molecule as well as the type of immune reaction was switched towards Th2. These observations may be rationalised in different ways: a drastic change of the conformation caused by the hydrophilic substituent might hinder/prohibit the binding of ManPGN to known receptors. Alternatively, the immunological observations may point to the involvement of the macrophage mannose receptor (MR) in PGN recognition. As a first take in understanding the immunological behaviour of the new derivatives, we investigated the solution conformation of mannosylated PGM as well as that of the peptapeptide fragment (ManPP) using NMR spectroscopy and molecular modelling and compared the structures with that of the parent moelcule, PGM.1. Szilagyi L. Pristovsek P. MiniRev.Med.Chem. Vol 7. p.861 20072. Ribic R Habjanec L Brgles M Tomic S Tomasic J. Bioorg. Med. Chem 17 6096–6105 20093. Feher, K.; Pristovsek, P.; Szilagyi, L.; Ljevakovic, D.; Tomasic, J. Bioorg. Med. Chem., 2003, 11, 3133" @default.
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- W2562665623 date "2012-01-01" @default.
- W2562665623 modified "2023-09-27" @default.
- W2562665623 title "Conformational investigations of mannosylated peptidoglycan derivatives with immunomodulating properties" @default.
- W2562665623 hasPublicationYear "2012" @default.
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