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- W2562685286 abstract "PAKs, p21-activated kinases, play central roles and act as converging junctions for discrete signals elicited on the cell surface and for a number of intracellular signaling cascades. PAKs phosphorylate a vast number of substrates and act by remodeling cytoskeleton, employing scaffolding, and relocating to distinct subcellular compartments. PAKs affect wide range of processes that are crucial to the cell from regulation of cell motility, survival, redox, metabolism, cell cycle, proliferation, transformation, stress, inflammation, to gene expression. Understandably, their dysregulation disrupts cellular homeostasis and severely impacts key cell functions, and many of those are implicated in a number of human diseases including cancers, neurological disorders, and cardiac disorders. Here we provide an overview of the members of the PAK family and their current status. We give special emphasis to PAK1 and PAK4, the prototypes of groups I and II, for their profound roles in cancer, the nervous system, and the heart. We also highlight other family members. We provide our perspective on the current advancements, their growing importance as strategic therapeutic targets, and our vision on the future of PAKs." @default.
- W2562685286 created "2017-01-06" @default.
- W2562685286 creator A5015628655 @default.
- W2562685286 creator A5032396875 @default.
- W2562685286 creator A5075000175 @default.
- W2562685286 creator A5081844561 @default.
- W2562685286 date "2017-03-01" @default.
- W2562685286 modified "2023-10-04" @default.
- W2562685286 title "Structure, biochemistry, and biology of PAK kinases" @default.
- W2562685286 cites W1250005677 @default.
- W2562685286 cites W1487918137 @default.
- W2562685286 cites W1490646520 @default.
- W2562685286 cites W1496017988 @default.
- W2562685286 cites W1517889790 @default.
- W2562685286 cites W1518370492 @default.
- W2562685286 cites W1531055064 @default.
- W2562685286 cites W1539701480 @default.
- W2562685286 cites W1558158633 @default.
- W2562685286 cites W1563080703 @default.
- W2562685286 cites W1571441798 @default.
- W2562685286 cites W1580332068 @default.
- W2562685286 cites W1662447390 @default.
- W2562685286 cites W1783132379 @default.
- W2562685286 cites W1812277299 @default.
- W2562685286 cites W1822443335 @default.
- W2562685286 cites W1824887730 @default.
- W2562685286 cites W1854827066 @default.
- W2562685286 cites W1933236632 @default.
- W2562685286 cites W1933679718 @default.
- W2562685286 cites W1940860699 @default.
- W2562685286 cites W1943425290 @default.
- W2562685286 cites W1949487746 @default.
- W2562685286 cites W1963697129 @default.
- W2562685286 cites W1965261716 @default.
- W2562685286 cites W1967814766 @default.
- W2562685286 cites W1969219693 @default.
- W2562685286 cites W1970402401 @default.
- W2562685286 cites W1973351678 @default.
- W2562685286 cites W1973565476 @default.
- W2562685286 cites W1973848203 @default.
- W2562685286 cites W1973891472 @default.
- W2562685286 cites W1974268455 @default.
- W2562685286 cites W1974468232 @default.
- W2562685286 cites W1974937739 @default.
- W2562685286 cites W1975183482 @default.
- W2562685286 cites W1976033816 @default.
- W2562685286 cites W1976350738 @default.
- W2562685286 cites W1976755513 @default.
- W2562685286 cites W1977660494 @default.
- W2562685286 cites W1979400580 @default.
- W2562685286 cites W1980516263 @default.
- W2562685286 cites W1981580511 @default.
- W2562685286 cites W1982194496 @default.
- W2562685286 cites W1983017346 @default.
- W2562685286 cites W1983673557 @default.
- W2562685286 cites W1984291872 @default.
- W2562685286 cites W1985086842 @default.
- W2562685286 cites W1987190589 @default.
- W2562685286 cites W1987821958 @default.
- W2562685286 cites W1987888650 @default.
- W2562685286 cites W1988684454 @default.
- W2562685286 cites W1989979780 @default.
- W2562685286 cites W1990058106 @default.
- W2562685286 cites W1991253526 @default.
- W2562685286 cites W1992729697 @default.
- W2562685286 cites W1992988824 @default.
- W2562685286 cites W1993454819 @default.
- W2562685286 cites W1998046127 @default.
- W2562685286 cites W1998232305 @default.
- W2562685286 cites W2000237287 @default.
- W2562685286 cites W2000426106 @default.
- W2562685286 cites W2001224271 @default.
- W2562685286 cites W2002339899 @default.
- W2562685286 cites W2003024744 @default.
- W2562685286 cites W2003173961 @default.
- W2562685286 cites W2003569663 @default.
- W2562685286 cites W2006547875 @default.
- W2562685286 cites W2009430002 @default.
- W2562685286 cites W2009636209 @default.
- W2562685286 cites W2010110662 @default.
- W2562685286 cites W2010934863 @default.
- W2562685286 cites W2011756230 @default.
- W2562685286 cites W2012682371 @default.
- W2562685286 cites W2013377296 @default.
- W2562685286 cites W2014304886 @default.
- W2562685286 cites W2014644181 @default.
- W2562685286 cites W2014981122 @default.
- W2562685286 cites W2015636127 @default.
- W2562685286 cites W2018097702 @default.
- W2562685286 cites W2019035938 @default.
- W2562685286 cites W2021289405 @default.
- W2562685286 cites W2022185380 @default.
- W2562685286 cites W2022398967 @default.
- W2562685286 cites W2022440206 @default.
- W2562685286 cites W2023568503 @default.
- W2562685286 cites W2023612761 @default.
- W2562685286 cites W2023824944 @default.
- W2562685286 cites W2024598372 @default.