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- W2562747093 abstract "AbstractMelatonin modulates immune function through its membrane-bound MT1 and MT2 receptors in mammalian system. Adrenal glucocorticoid, an important metabolic hormone is known as a immuno-compromising agent. In the present study, we investigated the effect of dexamethasone on melatonin receptor proteins in spleen tissue and anti-klh-IgG response in Swiss albino mice. Melatonin treatment increased the MT1 and MT2 receptor proteins and anti-klh-IgG than control mice. Dexamethasone treatment increased MT2 receptor protein and anti-klh-IgG than melatonin-treated group. Dexamethasone treatment to melatonin-treated mice showed additive effects and maximally increased the anti-klh-IgG than other experimental groups. A decrease in glucocorticoid receptor (GR) protein was noted in melatonin treated as well as dexamethasone-treated mice. Dexamethasone significantly increased MT2 melatonin receptor protein in spleen and anti-klh-IgG and additively increased anti-klh-IgG when supplemented along with melatonin. Ther..." @default.
- W2562747093 created "2017-01-06" @default.
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- W2562747093 date "2016-12-20" @default.
- W2562747093 modified "2023-09-24" @default.
- W2562747093 title "Dexamethasone modulates melatonin MT2 receptor expression in splenic tissue and humoral immune response in mice" @default.
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- W2562747093 doi "https://doi.org/10.1080/09291016.2016.1268330" @default.
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