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- W2562770918 abstract "Background and aim Chronic and progressive nature of COPD necessitates the patients to regularly self-administer inhaled medication. Inhalation effort required and flow rates achieved through DPIs, are some of the important considerations while selecting dry power inhalers (DPIs). Here, we present the comparison of the peak inspiratory flow (PIF) rates achieved by COPD patients, with varying degrees of airflow limitation, through three types of DPIs (Breezhaler®, Ellipta® and HandiHaler®). We also assessed the effect of severity of airflow limitation on PIF rates. Methods This randomised, open-label, multicentre and cross-over study recruited patients with moderate-to-very severe airflow limitation (GOLD 2014) aged ≥40 years with a smoking history of ≥10 pack years. No active drug or placebo was administered during the study. After training the patients on correct use, inhalation flow profiles of patients were recorded using pressure tapped inhalers attached to a pressure transducer. For each patient, the inhalation profile with the highest PIF rate, out of three replicate inhalations per device, was selected for analysis. The primary analysis was based on the per-protocol set comprising 93 patients who completed all three inhalations per device. A paired t-test was performed to compare PIF means between each combination of devices. Results In total, 97 COPD patients were randomised, of whom 96 completed the study and 93 patients (per-protocol set) were included in the analysis. The highest mean PIF rate (L/min ± SE) was observed with the Breezhaler® (107.5 ± 2.4), followed by the Ellipta® (80.0 ± 2.2) and the HandiHaler® (53.6 ± 2.1), in all patients (patients with moderate-to-very severe airflow limitation). The mean PIF rate (L/min) achieved via the Breezhaler® was higher vs the Ellipta® (mean difference[Δ] = 27.7; p Conclusions COPD patients with varying degree of airflow limitation (moderate-to-very severe COPD) achieved the highest PIF rates via the Breezhaler® compared with the Ellipta® or the HandiHaler® inhaler." @default.
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- W2562770918 date "2016-11-15" @default.
- W2562770918 modified "2023-09-23" @default.
- W2562770918 title "P288 Copd patients with varying severity of airflow limitation achieve highest peak inspiratory flow rate via the breezhaler® inhaler compared to the ellipta® or the handihaler® dry powder inhalers" @default.
- W2562770918 doi "https://doi.org/10.1136/thoraxjnl-2016-209333.431" @default.
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