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- W2562783270 abstract "Monitoring blood coagulation is an important issue in the surgeries and the treatment of cardiovascular diseases. In this work, we reported a novel strategy for the blood coagulation monitoring based on a micro-electromechanical film bulk acoustic resonator. The resonator was excited by a lateral electric field and operated under the shear mode with a frequency of 1.9 GHz. According to the apparent step-ladder curves of the frequency response to the change of blood viscoelasticity, the coagulation time (prothrombin time) and the coagulation kinetics were measured with the sample consumption of only 1 μl. The procoagulant activity of thromboplastin and the anticoagulant effect of heparin on the blood coagulation process were illustrated exemplarily. The measured prothrombin times showed a good linear correlation with R2=0.99969 and a consistency with the coefficient of variation less than 5% compared with the commercial coagulometer. The proposed film bulk acoustic sensor, which has the advantages of small size, light weight, low cost, simple operation and little sample consumption, is a promising device for miniaturized, online and automated analytical system for routine diagnostics of hemostatic status and personal health monitoring." @default.
- W2562783270 created "2017-01-06" @default.
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- W2562783270 date "2017-05-01" @default.
- W2562783270 modified "2023-10-15" @default.
- W2562783270 title "Micro-electromechanical film bulk acoustic sensor for plasma and whole blood coagulation monitoring" @default.
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- W2562783270 doi "https://doi.org/10.1016/j.bios.2016.12.063" @default.
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