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• W2562805191 abstract "Objective: Olmesartan medoxomil (OLM) is an antihypertensive drug with low oral bioavailability (28%) resulting from poor aqueous solubility, presystemic metabolism and P-glycoprotein mediated efflux. The present investigation studies the role of lipid nanocarriers in enhancing the OLM bioavailability through oral delivery.Materials and methods: Solid lipid nanoparticles (SLN) were prepared by solvent emulsion-evaporation method. Statistical tools like regression analysis and Pareto charts were used to detect the important factors effecting the formulations. Formulation and process parameters were then optimized using mean effect plot and contour plots. The formulations were characterized for particle size, size distribution, surface charge, percentage of drug entrapped in nanoparticles, drug–excipients interactions, powder X-ray diffraction analysis and drug release in vitro.Results and discussion: The optimized formulation comprised glyceryl monostearate, soya phosphatidylcholine and Tween 80 as lipid, co-emulsifier and surfactant, respectively, with an average particle size of 100 nm, PDI 0.291, zeta potential of −23.4 mV and 78% entrapment efficiency. Pharmacokinetic evaluation in male Sprague Dawley rats revealed 2.32-fold enhancement in relative bioavailability of drug from SLN when compared to that of OLM plain drug on oral administration.Conclusion: In conclusion, SLN show promising approaches as a vehicle for oral delivery of drugs like OLM." @default.
• W2562805191 created "2017-01-06" @default.
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• W2562805191 date "2017-01-08" @default.
• W2562805191 modified "2023-09-30" @default.
• W2562805191 title "Solid lipid nanoparticles as vesicles for oral delivery of olmesartan medoxomil: formulation, optimization and <i>in vivo</i> evaluation" @default.
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• W2562805191 doi "https://doi.org/10.1080/03639045.2016.1275666" @default.
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