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- W2562806907 abstract "Osteochondral allograft transplantation is a useful technique to manage larger articular cartilage inju- ries. One factor that may compromise the effectiveness of this procedure is chondrocyte cell death that occurs during the storage, preparation, and implantation of the osteo- chondral grafts. Loss of viable chondrocytes may negatively affect osteochondral edge integration and long- term function. A better understanding of the mechanisms responsible for chondrocyte loss could lead to interventions designed to decrease cell death and improve results. Recent studies indicate that apoptosis, or programmed cell death, is responsible for much of the chondrocyte death associated with osteochondral allograft transplantation. Theoretically, some of these cells can be rescued by blocking important apoptotic mediators. We review the role of apoptosis in cartilage degeneration, focusing on apoptosis associated with osteochondral transplantation. We also review the pathways thought to be responsible for regulating chon- drocyte apoptosis, as well as experiments testing inhibitors of the apoptotic pathway. These data suggest that key contributors to the apoptotic process can be manipulated to enhance chondrocyte survival. This knowledge may lead to better surgical outcomes for osteochondral transplantation." @default.
- W2562806907 created "2017-01-06" @default.
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- W2562806907 date "2008-01-01" @default.
- W2562806907 modified "2023-09-26" @default.
- W2562806907 title "Implications for Osteochondral Allograft Transplantation" @default.
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