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• W2562830517 abstract "High dietary phosphorus (P) intake has acute negative effects on calcium (Ca) and bone metabolism, but long-term clinical data are contradictory. We hypothesized that high P intake is associated with impaired bone health as suggested by earlier short-term studies on bone metabolism. In this cross-sectional study, we investigated associations between dietary P intake, bone traits in the radius and tibia, and bone turnover in a population-based sample of 37- to 47-year-old Caucasian premenopausal women (n=333) and men (n=179) living in Southern Finland (60°N). We used various regression models in an elaboration approach to elucidate the role of P intake in bone traits and turnover. The addition of relevant covariates to the models mainly removed the significance of P intake as a determinant of bone traits. In the final regression model (P intake, weight, height, age, Ca intake, serum 25-hydroxyvitamin D, physical activity, smoking, contraceptive use in women), P intake was slightly positively associated only with bone mineral content and cross-sectional cortical bone area in the tibia of men. Among women, inclusion of Ca removed all existing significance in the crude models for any bone trait. In women P intake was negatively associated with the bone formation marker serum intact pro-collagen type I amino-terminal propeptide, whereas no association was present between P intake and bone turnover in men. In conclusion, these findings disagree with the hypothesis; P intake was not deleteriously associated with bone traits; however, P intake may negatively contribute to bone formation among women." @default.
• W2562830517 created "2017-01-06" @default.
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• W2562830517 date "2017-01-01" @default.
• W2562830517 modified "2023-10-16" @default.
• W2562830517 title "Dietary phosphorus intake is negatively associated with bone formation among women and positively associated with some bone traits among men—a cross-sectional study in middle-aged Caucasians" @default.
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• W2562830517 doi "https://doi.org/10.1016/j.nutres.2016.12.009" @default.
• W2562830517 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28215315" @default.
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