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• W2562863032 abstract "Nucleic acid‐sensing toll‐like receptors (TLRs) (3, 7, 8, 9) have a role both in antiviral innate immunity and in autoimmune disorders. We assessed the expression of TLR 3, 7, 8 and 9 in human and mouse pancreas focusing on the subpopulations of cells in the Langerhans islets. We studied eight human samples with normal pancreatic islets and two samples from patients with type 1 diabetes. Additionally, 10 CD ‐1 mouse pancreases were analysed. Immunohistochemical double‐stainings for the TLR s and insulin, glucagon or somatostatin, respectively, were performed along with appropriate controls. In human pancreas, strong immunoreaction of TLR 7 and TLR 8 was observed in the insulin‐positive beta cells, whereas glucagon‐ or somatostatin‐expressing cells of the islets were weakly stained or negative. In type 1 diabetes, the expression in islets was weak or lost ( TLR 7: p = 0.014, TLR 8: p = 0.053), correlating with loss of beta cells. TLR 3 and 9 were expressed only weakly with no correlation with specific cell types. In mouse pancreas, only TLR 9 was detected. Intra‐pancreatic nerve ganglia strongly expressed TLR 7. The strong expression of TLR 7 and TLR 8 in the beta cells of normal human islets could be an important piece in the puzzle of type 1 diabetes pathogenesis, and be linked with destruction of this particular subpopulation of the islet cells. In normal mice, only TLR 9 can be constantly detected in the islets, highlighting differences between the species." @default.
• W2562863032 created "2017-01-06" @default.
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• W2562863032 date "2016-12-28" @default.
• W2562863032 modified "2023-10-17" @default.
• W2562863032 title "Localization of nucleic acid-sensing toll-like receptors in human and mouse pancreas" @default.
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• W2562863032 doi "https://doi.org/10.1111/apm.12632" @default.
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• W2562863032 hasPublicationYear "2016" @default.
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