Matches in SemOpenAlex for { <https://semopenalex.org/work/W2562953325> ?p ?o ?g. }
- W2562953325 endingPage "e0168493" @default.
- W2562953325 startingPage "e0168493" @default.
- W2562953325 abstract "Little is known about disorder-specific biomarkers of bipolar disorder (BD) and major depressive disorder (MDD). Our aim was to determine a neural substrate that could be used to distinguish BD from MDD. Our study included a BD group (10 patients with BD, 10 first-degree relatives (FDRs) of individuals with BD), MDD group (17 patients with MDD, 17 FDRs of individuals with MDD), and 27 healthy individuals. Structural and functional brain abnormalities were evaluated by voxel-based morphometry and a trail making test (TMT), respectively. The BD group showed a significant main effect of diagnosis in the gray matter (GM) volume of the anterior cingulate cortex (ACC; p = 0.01) and left insula (p < 0.01). FDRs of individuals with BD showed significantly smaller left ACC GM volume than healthy subjects (p < 0.01), and patients with BD showed significantly smaller ACC (p < 0.01) and left insular GM volume (p < 0.01) than healthy subjects. The MDD group showed a tendency toward a main effect of diagnosis in the right and left insular GM volume. The BD group showed a significantly inverse correlation between the left insular GM volume and TMT-A scores (p < 0.05). Our results suggest that the ACC volume could be a distinct endophenotype of BD, while the insular volume could be a shared BD and MDD endophenotype. Moreover, the insula could be associated with cognitive decline and poor outcome in BD." @default.
- W2562953325 created "2017-01-06" @default.
- W2562953325 creator A5006153455 @default.
- W2562953325 creator A5026263534 @default.
- W2562953325 creator A5026328009 @default.
- W2562953325 creator A5029924703 @default.
- W2562953325 creator A5031409314 @default.
- W2562953325 creator A5042989894 @default.
- W2562953325 creator A5062467755 @default.
- W2562953325 creator A5063554725 @default.
- W2562953325 creator A5063738564 @default.
- W2562953325 creator A5089927737 @default.
- W2562953325 date "2016-12-28" @default.
- W2562953325 modified "2023-09-27" @default.
- W2562953325 title "Distinct and Shared Endophenotypes of Neural Substrates in Bipolar and Major Depressive Disorders" @default.
- W2562953325 cites W1568596887 @default.
- W2562953325 cites W1605499779 @default.
- W2562953325 cites W166714271 @default.
- W2562953325 cites W1811549782 @default.
- W2562953325 cites W1881397201 @default.
- W2562953325 cites W1966717548 @default.
- W2562953325 cites W1967063167 @default.
- W2562953325 cites W1968487444 @default.
- W2562953325 cites W1970090972 @default.
- W2562953325 cites W1975355183 @default.
- W2562953325 cites W1978165201 @default.
- W2562953325 cites W1979203160 @default.
- W2562953325 cites W1981253098 @default.
- W2562953325 cites W1982931669 @default.
- W2562953325 cites W1987493933 @default.
- W2562953325 cites W1992416557 @default.
- W2562953325 cites W1993859837 @default.
- W2562953325 cites W1996881939 @default.
- W2562953325 cites W1999331325 @default.
- W2562953325 cites W2000413381 @default.
- W2562953325 cites W2004850661 @default.
- W2562953325 cites W2005648405 @default.
- W2562953325 cites W2016414626 @default.
- W2562953325 cites W2019604064 @default.
- W2562953325 cites W2020930904 @default.
- W2562953325 cites W2020982510 @default.
- W2562953325 cites W2023682802 @default.
- W2562953325 cites W2025774571 @default.
- W2562953325 cites W2029064583 @default.
- W2562953325 cites W2030109188 @default.
- W2562953325 cites W2035897560 @default.
- W2562953325 cites W2041198871 @default.
- W2562953325 cites W2043065112 @default.
- W2562953325 cites W2051410142 @default.
- W2562953325 cites W2052950175 @default.
- W2562953325 cites W2057970036 @default.
- W2562953325 cites W2058161128 @default.
- W2562953325 cites W2058923243 @default.
- W2562953325 cites W2061445400 @default.
- W2562953325 cites W2062607372 @default.
- W2562953325 cites W2070991892 @default.
- W2562953325 cites W2072530573 @default.
- W2562953325 cites W2073288993 @default.
- W2562953325 cites W2075825551 @default.
- W2562953325 cites W2079969863 @default.
- W2562953325 cites W2083733140 @default.
- W2562953325 cites W2090953041 @default.
- W2562953325 cites W2091687415 @default.
- W2562953325 cites W2094291705 @default.
- W2562953325 cites W2094630986 @default.
- W2562953325 cites W2095068146 @default.
- W2562953325 cites W2098877785 @default.
- W2562953325 cites W2098894213 @default.
- W2562953325 cites W2099498537 @default.
- W2562953325 cites W2101368129 @default.
- W2562953325 cites W2113303690 @default.
- W2562953325 cites W2114613490 @default.
- W2562953325 cites W2114904714 @default.
- W2562953325 cites W2120364592 @default.
- W2562953325 cites W2120694965 @default.
- W2562953325 cites W2123412124 @default.
- W2562953325 cites W2123593542 @default.
- W2562953325 cites W2124484391 @default.
- W2562953325 cites W2124571614 @default.
- W2562953325 cites W2129624700 @default.
- W2562953325 cites W2132135247 @default.
- W2562953325 cites W2136022845 @default.
- W2562953325 cites W2139401165 @default.
- W2562953325 cites W2150924595 @default.
- W2562953325 cites W2152610610 @default.
- W2562953325 cites W2153729095 @default.
- W2562953325 cites W2167659819 @default.
- W2562953325 cites W2198940986 @default.
- W2562953325 cites W2471744332 @default.
- W2562953325 cites W4296396329 @default.
- W2562953325 doi "https://doi.org/10.1371/journal.pone.0168493" @default.
- W2562953325 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5193412" @default.
- W2562953325 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28030612" @default.
- W2562953325 hasPublicationYear "2016" @default.
- W2562953325 type Work @default.
- W2562953325 sameAs 2562953325 @default.
- W2562953325 citedByCount "24" @default.
- W2562953325 countsByYear W25629533252017 @default.