FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2562955704> ?p ?o ?g. }

• W2562955704 endingPage "176" @default.
• W2562955704 startingPage "167" @default.
• W2562955704 abstract "Quercetin is a plant flavonoid with strong antioxidant and antiinflammatory properties interesting for skin protection. However, its poor water solubility limits its penetration and so its efficiency on skin. For this purpose, quercetin lipid nanocapsules were formulated implementing phase inversion technique wherein several modifications were introduced to enhance quercetin loading. Quercetin lipid nanocapsules were formulated with two particle size range, (50 nm and 20 nm) allowing a drug loading of 18.6 and 32 mM respectively. The successful encapsulation of quercetin within lipid nanocapsules increased its apparent water solubility by more than 5000 fold (from 0.5 μg/ml to about 5 mg/ml). The physicochemical properties of these formulations such as surface charge, stability and morphology were characterized. Lipid nanocapsules had spherical shape and were stable for 28 days at 25 °C. Quercetin release from lipid nanocapsules was studied and revealed a prolonged release kinetics during 24 h. Using DPPH assay, we demonstrated that the formulation process of lipid nanocapsules did not modify the antioxidant activity of quercetin in vitro (92.3%). With the goal of a future dermal application, quercetin lipid nanocapsules were applied to THP-1 monocytes and proved the cellular safety of the formulation up to 2 μg/ml of quercetin. Finally, formulated quercetin was as efficient as the crude form in the protection of THP-1 cells from oxidative stress by exogenous hydrogen peroxide. With its lipophilic nature and occlusive effect on skin, lipid nanocapsules present a promising strategy to deliver quercetin to skin tissue and can be of value for other poorly water soluble drug candidates." @default.
• W2562955704 created "2017-01-06" @default.
• W2562955704 creator A5013151320 @default.
• W2562955704 creator A5016006405 @default.
• W2562955704 creator A5040902955 @default.
• W2562955704 creator A5048402911 @default.
• W2562955704 creator A5065684309 @default.
• W2562955704 creator A5091340307 @default.
• W2562955704 date "2017-02-01" @default.
• W2562955704 modified "2023-09-30" @default.
• W2562955704 title "Dermal quercetin lipid nanocapsules: Influence of the formulation on antioxidant activity and cellular protection against hydrogen peroxide" @default.
• W2562955704 cites W1205374584 @default.
• W2562955704 cites W1966595448 @default.
• W2562955704 cites W1968418753 @default.
• W2562955704 cites W1969191668 @default.
• W2562955704 cites W1972281600 @default.
• W2562955704 cites W1973633039 @default.
• W2562955704 cites W1976127076 @default.
• W2562955704 cites W1976175389 @default.
• W2562955704 cites W1976774076 @default.
• W2562955704 cites W1977933517 @default.
• W2562955704 cites W1979110270 @default.
• W2562955704 cites W1985786979 @default.
• W2562955704 cites W1986464172 @default.
• W2562955704 cites W1989492660 @default.
• W2562955704 cites W1989530212 @default.
• W2562955704 cites W1989619366 @default.
• W2562955704 cites W1991931785 @default.
• W2562955704 cites W1992439632 @default.
• W2562955704 cites W1993101867 @default.
• W2562955704 cites W1993112302 @default.
• W2562955704 cites W1995963629 @default.
• W2562955704 cites W1997728813 @default.
• W2562955704 cites W2001893670 @default.
• W2562955704 cites W2003996184 @default.
• W2562955704 cites W2005703936 @default.
• W2562955704 cites W2005986992 @default.
• W2562955704 cites W2009630088 @default.
• W2562955704 cites W2012387037 @default.
• W2562955704 cites W2014214126 @default.
• W2562955704 cites W2014978180 @default.
• W2562955704 cites W2018793025 @default.
• W2562955704 cites W2025735078 @default.
• W2562955704 cites W2025811188 @default.
• W2562955704 cites W2027644971 @default.
• W2562955704 cites W2028377177 @default.
• W2562955704 cites W2028761028 @default.
• W2562955704 cites W2029390954 @default.
• W2562955704 cites W2031596649 @default.
• W2562955704 cites W2034082246 @default.
• W2562955704 cites W2034138646 @default.
• W2562955704 cites W2040448941 @default.
• W2562955704 cites W2042194530 @default.
• W2562955704 cites W2043699346 @default.
• W2562955704 cites W2045517854 @default.
• W2562955704 cites W2047734064 @default.
• W2562955704 cites W2051424055 @default.
• W2562955704 cites W2052768789 @default.
• W2562955704 cites W2059215900 @default.
• W2562955704 cites W2061346349 @default.
• W2562955704 cites W2062703926 @default.
• W2562955704 cites W2063839346 @default.
• W2562955704 cites W2064954029 @default.
• W2562955704 cites W2073667026 @default.
• W2562955704 cites W2077050915 @default.
• W2562955704 cites W2081534467 @default.
• W2562955704 cites W2082200673 @default.
• W2562955704 cites W2082865634 @default.
• W2562955704 cites W2086381409 @default.
• W2562955704 cites W2086420167 @default.
• W2562955704 cites W2086742761 @default.
• W2562955704 cites W2088067817 @default.
• W2562955704 cites W2089210293 @default.
• W2562955704 cites W2090821599 @default.
• W2562955704 cites W2091480220 @default.
• W2562955704 cites W2093666893 @default.
• W2562955704 cites W2124660605 @default.
• W2562955704 cites W2127901289 @default.
• W2562955704 cites W2129195387 @default.
• W2562955704 cites W2141162588 @default.
• W2562955704 cites W2142229269 @default.
• W2562955704 cites W2155294852 @default.
• W2562955704 cites W2156013098 @default.
• W2562955704 cites W2156339880 @default.
• W2562955704 cites W2162460931 @default.
• W2562955704 cites W2163150600 @default.
• W2562955704 cites W2166551288 @default.
• W2562955704 cites W2168556140 @default.
• W2562955704 cites W2177900183 @default.
• W2562955704 cites W2290937619 @default.
• W2562955704 cites W2561759163 @default.
• W2562955704 cites W4255761030 @default.
• W2562955704 doi "https://doi.org/10.1016/j.ijpharm.2016.12.043" @default.
• W2562955704 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28011344" @default.
• W2562955704 hasPublicationYear "2017" @default.
• W2562955704 type Work @default.
• W2562955704 sameAs 2562955704 @default.
• W2562955704 citedByCount "53" @default.

• next