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- W2562979084 abstract "Nanoparticle-based delivery systems provide new opportunities to overcome the limitations associated with traditional drug therapy and aim to achieve both therapeutic and diagnostic functions in the same platform. Nanoparticle biodistribution and uptake by the reticuloendothelial system warranted the design of nanoparticles to evade rapid uptake such as lipid liposomes, albumin carriers, and PEGylation. Nanopharmaceuticals have improved biodistribution and targeting features as well as the potential of stimuli-sensitive microenvironments payload release. Nanoparticle albumin-bound (nabTM) technology is a nanotechnology-based drug delivery platform that exploits the natural properties of albumin to achieve a safe, solvent-free, and targeted drug delivery. Apart from cancer therapy, nanoparticles have become valuable in vaccine therapy. Although most research and commercial nanoparticles are administered parenterally, nanoparticles have proven to enable oral drug delivery by increasing oral bioavailability. An understanding of the physicochemical and biological parameters affecting the quality, and efficacy of the nanopharmaceuticals will enable “follow-on” nanotherapeutics to gain easier access to the market." @default.
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- W2562979084 date "2016-12-02" @default.
- W2562979084 modified "2023-10-17" @default.
- W2562979084 title "History: Potential, Challenges, and Future Development in Nanopharmaceutical Research and Industry" @default.
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- W2562979084 doi "https://doi.org/10.1002/9783527800681.ch1" @default.
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