Matches in SemOpenAlex for { <https://semopenalex.org/work/W2562994992> ?p ?o ?g. }
Showing items 1 to 71 of
71
with 100 items per page.
- W2562994992 abstract "Cancer is a major public health burden in both developed and developing countries. The current conventional cancer therapies like chemotherapy are expensive and inaccessible to many cancer patients. Commercial and wild edible mushrooms are becoming more important for their nutritional value and are becoming an alternative source of immune modulation and anticancer agents. Although Previous studies with Trametes versicolor mushroom from various parts of the world have demonstrated antiproliferative activity on various cancer cell lines, the antiproliferative activity of the recently identified Kenyan T. versicolor mushroom have not been studied. This study examined the in vitro antiproliferative activity of an aqueous extract of the Kenyan T. versicolor mushroom on breast cancer (4T1), prostate cancer (DU145), hepatocellular carcinoma (HCC), rat normal intestinal epithelial cells (IEC-6) and African green monkey normal kidney (vero) cell lines using MTT assay. The results demonstrated that the T. versicolor extract at 1.37 μg/ml to 1000 μg/ml dose-dependently inhibited the proliferation of DU145 and 4T1cell lines with IC50 values: DU145 (71.2 μg/ml) and 4T1 (188.5 μg/ml). The extract however did not exert any significant antiproliferative effect on HCC, IEC-6 and Vero cell lines (IC50E1000 μg/ml) when compared with a chemotherapeutic anticancer drug, tamoxifen (p<0.05), confirming the tumor-selective cytotoxicity on cancer cell lines and its safety on normal cell lines. In all cell lines, the extract showed a significant difference in inhibition of cell proliferation between the untreated cells and the highest concentration (1000 μg/ml) (p<0.05). Presence of phytochemicals such as saponins, tannins, steroids, terpenoids and flavonoids in the T. vesicolor extract used might be the probable reason for its antiproliferative activity." @default.
- W2562994992 created "2017-01-06" @default.
- W2562994992 creator A5062140932 @default.
- W2562994992 creator A5084325774 @default.
- W2562994992 creator A5087477868 @default.
- W2562994992 date "2016-01-01" @default.
- W2562994992 modified "2023-10-02" @default.
- W2562994992 title "Antiproliferative Activity of Kenyan Trametes versicolor Aqueous Extract on Selected Cancer and Normal Cell Lines" @default.
- W2562994992 doi "https://doi.org/10.4172/1948-5956.1000427" @default.
- W2562994992 hasPublicationYear "2016" @default.
- W2562994992 type Work @default.
- W2562994992 sameAs 2562994992 @default.
- W2562994992 citedByCount "2" @default.
- W2562994992 countsByYear W25629949922017 @default.
- W2562994992 countsByYear W25629949922019 @default.
- W2562994992 crossrefType "journal-article" @default.
- W2562994992 hasAuthorship W2562994992A5062140932 @default.
- W2562994992 hasAuthorship W2562994992A5084325774 @default.
- W2562994992 hasAuthorship W2562994992A5087477868 @default.
- W2562994992 hasBestOaLocation W25629949921 @default.
- W2562994992 hasConcept C121608353 @default.
- W2562994992 hasConcept C181199279 @default.
- W2562994992 hasConcept C187651312 @default.
- W2562994992 hasConcept C18903297 @default.
- W2562994992 hasConcept C2781170783 @default.
- W2562994992 hasConcept C2993907526 @default.
- W2562994992 hasConcept C2994372470 @default.
- W2562994992 hasConcept C54355233 @default.
- W2562994992 hasConcept C55493867 @default.
- W2562994992 hasConcept C556039675 @default.
- W2562994992 hasConcept C71924100 @default.
- W2562994992 hasConcept C76935637 @default.
- W2562994992 hasConcept C81885089 @default.
- W2562994992 hasConcept C86803240 @default.
- W2562994992 hasConcept C96232424 @default.
- W2562994992 hasConcept C98274493 @default.
- W2562994992 hasConceptScore W2562994992C121608353 @default.
- W2562994992 hasConceptScore W2562994992C181199279 @default.
- W2562994992 hasConceptScore W2562994992C187651312 @default.
- W2562994992 hasConceptScore W2562994992C18903297 @default.
- W2562994992 hasConceptScore W2562994992C2781170783 @default.
- W2562994992 hasConceptScore W2562994992C2993907526 @default.
- W2562994992 hasConceptScore W2562994992C2994372470 @default.
- W2562994992 hasConceptScore W2562994992C54355233 @default.
- W2562994992 hasConceptScore W2562994992C55493867 @default.
- W2562994992 hasConceptScore W2562994992C556039675 @default.
- W2562994992 hasConceptScore W2562994992C71924100 @default.
- W2562994992 hasConceptScore W2562994992C76935637 @default.
- W2562994992 hasConceptScore W2562994992C81885089 @default.
- W2562994992 hasConceptScore W2562994992C86803240 @default.
- W2562994992 hasConceptScore W2562994992C96232424 @default.
- W2562994992 hasConceptScore W2562994992C98274493 @default.
- W2562994992 hasIssue "11" @default.
- W2562994992 hasLocation W25629949921 @default.
- W2562994992 hasOpenAccess W2562994992 @default.
- W2562994992 hasPrimaryLocation W25629949921 @default.
- W2562994992 hasRelatedWork W2060307699 @default.
- W2562994992 hasRelatedWork W2094078672 @default.
- W2562994992 hasRelatedWork W2149286326 @default.
- W2562994992 hasRelatedWork W2298093885 @default.
- W2562994992 hasRelatedWork W2562994992 @default.
- W2562994992 hasRelatedWork W3040425006 @default.
- W2562994992 hasRelatedWork W3134731358 @default.
- W2562994992 hasRelatedWork W4213315268 @default.
- W2562994992 hasRelatedWork W4252325056 @default.
- W2562994992 hasRelatedWork W9122269 @default.
- W2562994992 hasVolume "8" @default.
- W2562994992 isParatext "false" @default.
- W2562994992 isRetracted "false" @default.
- W2562994992 magId "2562994992" @default.
- W2562994992 workType "article" @default.