FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2563013896> ?p ?o ?g. }

• W2563013896 abstract "Abstract Despite the success story of tyrosine kinase inhibitors (TKIs) for the treatment of Chronic Myeloid Leukemia (CML), patients can develop resistances against the drugs. The main known causes for resistance are mutations or over-expression of the BCR/ABL fusion protein, reduced bioavailability of the drugs and activation of compensatory molecular pathways. It is hypothesized that during disease progression, genomic instability of CML cells increases, which may lead to new genomic lesions harboring additional mechanisms of resistance. In this context, we studied genomic DNA profiles of 32 Imatinib resistant CML patients with high density 250K SNP arrays (Affymetrix). Molecular allelokaryotyping for allele specific copy number and loss of heterozygosity analysis was performed with the CNAG software. Single DNA samples from 27 patients were extracted after they had acquired resistance to Imatinib or alternative TKIs such as Nilotinib or Dasatinib. DNA from 12 patients could be analyzed in sequential samples from the initial diagnosis timepoint and a second timepoint upon the emergence of TKI resistance. All patients were positive for BCR/ABL by PCR and FISH. 10 relapse patient samples had known BCR/ABL mutations of which two were T315I mutations. High density allelokaryotyping confirmed pre-existent data on unbalanced translocations, amplifications and deletions from routine cytogenetics: 5 samples displayed a genomic duplication of the BCR/ABL fusion gene, 4 samples had trisomy 8, 1 sample showed deletion of chromosome 17p, 1 sample had heterozygous deletion of chromosome 9. Apart from this, SNP array analysis revealed numerous new submicroscopic genomic lesions. After exclusion of genomic copy number polymorphisms (CNPs) by comparison to recorded CNPs in the UCSC Genome Browser (http://genome.ucsc.edu/) the following results were obtained: Two patients displayed common heterozygous microdeletions of the reciprocal ABL/BCR fusion product. Furthermore, single samples displayed heterozygous micro-deletions on chromosomes 1, 2, 10, 12, 15, 17, and 22 or microduplications on chromosomes 2,3,6, 8, 9, 11, 12, 14, 15, 22. The affected regions contained potentially interesting genes in respect to resistance to therapy such as tumor suppressor candidate MBP-1, apoptosis related protein RERE, metastasis associated gene MTA3, nuclear body associated gene SP100, alpha-T-catenin (CTNNA3), Cbl-interacting protein Sts-1 and the DNA repair associated gene RAD51. As a new genomic alteration in CML, we detected acquired uniparental disomy (UPD) in 5 samples with a common site of UPD on chromosome 19q in 2 patients. In conclusion, in 14 out of 39 TKI resistant cases, high density SNP arrays enabled us to identify submicroscopic copy number lesions and regions of UPD containing promising candidate genes, which merit further research as sites conferring TKI resistance." @default.
• W2563013896 created "2017-01-06" @default.
• W2563013896 creator A5029332875 @default.
• W2563013896 creator A5042588749 @default.
• W2563013896 creator A5043414993 @default.
• W2563013896 creator A5047228096 @default.
• W2563013896 creator A5055601574 @default.
• W2563013896 creator A5057163472 @default.
• W2563013896 creator A5061189755 @default.
• W2563013896 creator A5068563937 @default.
• W2563013896 creator A5078387402 @default.
• W2563013896 creator A5082903377 @default.
• W2563013896 date "2008-11-16" @default.
• W2563013896 modified "2023-09-29" @default.
• W2563013896 title "High Density SNP Array Analysis of Tyrosine Kinase Inhibitor (TKI) Resistant Chronic Myeloid Leukemia (CML) Shows Secondary Genomic Alterations" @default.
• W2563013896 doi "https://doi.org/10.1182/blood.v112.11.3182.3182" @default.
• W2563013896 hasPublicationYear "2008" @default.
• W2563013896 type Work @default.
• W2563013896 sameAs 2563013896 @default.
• W2563013896 citedByCount "0" @default.
• W2563013896 crossrefType "journal-article" @default.
• W2563013896 hasAuthorship W2563013896A5029332875 @default.
• W2563013896 hasAuthorship W2563013896A5042588749 @default.
• W2563013896 hasAuthorship W2563013896A5043414993 @default.
• W2563013896 hasAuthorship W2563013896A5047228096 @default.
• W2563013896 hasAuthorship W2563013896A5055601574 @default.
• W2563013896 hasAuthorship W2563013896A5057163472 @default.
• W2563013896 hasAuthorship W2563013896A5061189755 @default.
• W2563013896 hasAuthorship W2563013896A5068563937 @default.
• W2563013896 hasAuthorship W2563013896A5078387402 @default.
• W2563013896 hasAuthorship W2563013896A5082903377 @default.
• W2563013896 hasConcept C104317684 @default.
• W2563013896 hasConcept C120821319 @default.
• W2563013896 hasConcept C121608353 @default.
• W2563013896 hasConcept C122060243 @default.
• W2563013896 hasConcept C135763542 @default.
• W2563013896 hasConcept C138626823 @default.
• W2563013896 hasConcept C141231307 @default.
• W2563013896 hasConcept C143425029 @default.
• W2563013896 hasConcept C153209595 @default.
• W2563013896 hasConcept C153911025 @default.
• W2563013896 hasConcept C166608930 @default.
• W2563013896 hasConcept C178169997 @default.
• W2563013896 hasConcept C2777413986 @default.
• W2563013896 hasConcept C2777583451 @default.
• W2563013896 hasConcept C2778729363 @default.
• W2563013896 hasConcept C2778820342 @default.
• W2563013896 hasConcept C2779536868 @default.
• W2563013896 hasConcept C3019892230 @default.
• W2563013896 hasConcept C502942594 @default.
• W2563013896 hasConcept C54355233 @default.
• W2563013896 hasConcept C552990157 @default.
• W2563013896 hasConcept C86803240 @default.
• W2563013896 hasConceptScore W2563013896C104317684 @default.
• W2563013896 hasConceptScore W2563013896C120821319 @default.
• W2563013896 hasConceptScore W2563013896C121608353 @default.
• W2563013896 hasConceptScore W2563013896C122060243 @default.
• W2563013896 hasConceptScore W2563013896C135763542 @default.
• W2563013896 hasConceptScore W2563013896C138626823 @default.
• W2563013896 hasConceptScore W2563013896C141231307 @default.
• W2563013896 hasConceptScore W2563013896C143425029 @default.
• W2563013896 hasConceptScore W2563013896C153209595 @default.
• W2563013896 hasConceptScore W2563013896C153911025 @default.
• W2563013896 hasConceptScore W2563013896C166608930 @default.
• W2563013896 hasConceptScore W2563013896C178169997 @default.
• W2563013896 hasConceptScore W2563013896C2777413986 @default.
• W2563013896 hasConceptScore W2563013896C2777583451 @default.
• W2563013896 hasConceptScore W2563013896C2778729363 @default.
• W2563013896 hasConceptScore W2563013896C2778820342 @default.
• W2563013896 hasConceptScore W2563013896C2779536868 @default.
• W2563013896 hasConceptScore W2563013896C3019892230 @default.
• W2563013896 hasConceptScore W2563013896C502942594 @default.
• W2563013896 hasConceptScore W2563013896C54355233 @default.
• W2563013896 hasConceptScore W2563013896C552990157 @default.
• W2563013896 hasConceptScore W2563013896C86803240 @default.
• W2563013896 hasLocation W25630138961 @default.
• W2563013896 hasOpenAccess W2563013896 @default.
• W2563013896 hasPrimaryLocation W25630138961 @default.
• W2563013896 hasRelatedWork W1954367560 @default.
• W2563013896 hasRelatedWork W1967187400 @default.
• W2563013896 hasRelatedWork W1976529806 @default.
• W2563013896 hasRelatedWork W2125230290 @default.
• W2563013896 hasRelatedWork W2132171932 @default.
• W2563013896 hasRelatedWork W2465310360 @default.
• W2563013896 hasRelatedWork W2479408098 @default.
• W2563013896 hasRelatedWork W2552704622 @default.
• W2563013896 hasRelatedWork W2554842246 @default.
• W2563013896 hasRelatedWork W2557110867 @default.
• W2563013896 hasRelatedWork W2557928268 @default.
• W2563013896 hasRelatedWork W2566766506 @default.
• W2563013896 hasRelatedWork W2574534504 @default.
• W2563013896 hasRelatedWork W2579148820 @default.
• W2563013896 hasRelatedWork W2584166758 @default.
• W2563013896 hasRelatedWork W2586349746 @default.
• W2563013896 hasRelatedWork W2587789951 @default.
• W2563013896 hasRelatedWork W2591078219 @default.
• W2563013896 hasRelatedWork W2980838273 @default.
• W2563013896 hasRelatedWork W856510063 @default.
• W2563013896 isParatext "false" @default.
• W2563013896 isRetracted "false" @default.

• next