Matches in SemOpenAlex for { <https://semopenalex.org/work/W2563109049> ?p ?o ?g. }
- W2563109049 endingPage "175" @default.
- W2563109049 startingPage "167" @default.
- W2563109049 abstract "Si-miao-yong-an decoction (SMYAD), a traditional Chinese medicine formula, significantly reduced plasma TC, LDL-c levels and increased HDL-c level in hyperlipidemia rats. Liver function test and tissue section examination indicated that SMYAD improved liver function and reduced fat accumulation in hyperlipidemia rat liver. A LC-MS/MS method was established and well validated to evaluate major bile acids derived from cholesterol metabolism through the classic neutral pathway and the alternative acidic pathway (cholic acid, chenodeoxycholic acid and their taurine and glycine conjugates) in liver and plasma. Increased total 6 bile acids concentrations in both liver and plasma were observed after oral administration of 12g/kg/d, 24g/kg/d and 36g/kg/d of SMYAD in a dose dependent manner which contributed to eliminate of cholesterol. Cholic acid, taurocholic acid and glycocholic acid act as the main products of bile acid classic neutral synthesis pathway and show sharp increase (p<0.01) after treatment of SMYAD at dosage of 24-36g/kg/d. For liver samples, taurocholic acid level act as the largest growth section, while in plasma samples, cholic acid act as the largest growth section after SMYAD treatment, compared with Model group. By contrast, the main products of alternative acidic pathway (chenodeoxycholic acid and its glycine and taurine conjugates) show no significant increase after treatment of SMYAD. In conclusion, the cholesterol lowing effect of SMYAD may be related with the accelerated transformation of cholesterol into bile acids through the classic neutral pathway." @default.
- W2563109049 created "2017-01-06" @default.
- W2563109049 creator A5004244292 @default.
- W2563109049 creator A5011674133 @default.
- W2563109049 creator A5035321872 @default.
- W2563109049 creator A5071773009 @default.
- W2563109049 creator A5075146505 @default.
- W2563109049 date "2017-02-01" @default.
- W2563109049 modified "2023-10-17" @default.
- W2563109049 title "Promotion of classic neutral bile acids synthesis pathway is responsible for cholesterol-lowing effect of Si-miao-yong-an decoction: Application of LC–MS/MS method to determine 6 major bile acids in rat liver and plasma" @default.
- W2563109049 cites W1479742347 @default.
- W2563109049 cites W1541662874 @default.
- W2563109049 cites W1562832895 @default.
- W2563109049 cites W1758217366 @default.
- W2563109049 cites W1764294735 @default.
- W2563109049 cites W1828402659 @default.
- W2563109049 cites W1836594461 @default.
- W2563109049 cites W1932390491 @default.
- W2563109049 cites W1969464487 @default.
- W2563109049 cites W1969739207 @default.
- W2563109049 cites W1970541648 @default.
- W2563109049 cites W1971221745 @default.
- W2563109049 cites W1971403438 @default.
- W2563109049 cites W1974993651 @default.
- W2563109049 cites W1986427166 @default.
- W2563109049 cites W1992562748 @default.
- W2563109049 cites W2000076076 @default.
- W2563109049 cites W2006029780 @default.
- W2563109049 cites W2011237391 @default.
- W2563109049 cites W2016187822 @default.
- W2563109049 cites W2019000662 @default.
- W2563109049 cites W2037934558 @default.
- W2563109049 cites W2045084781 @default.
- W2563109049 cites W2054851194 @default.
- W2563109049 cites W2061831818 @default.
- W2563109049 cites W2062635407 @default.
- W2563109049 cites W2066344678 @default.
- W2563109049 cites W2066561101 @default.
- W2563109049 cites W2067548372 @default.
- W2563109049 cites W2079958819 @default.
- W2563109049 cites W2083446323 @default.
- W2563109049 cites W2092960198 @default.
- W2563109049 cites W2093325483 @default.
- W2563109049 cites W2096210401 @default.
- W2563109049 cites W2107841008 @default.
- W2563109049 cites W2118057359 @default.
- W2563109049 cites W2132279891 @default.
- W2563109049 cites W2143810054 @default.
- W2563109049 cites W2152993057 @default.
- W2563109049 cites W2155932961 @default.
- W2563109049 cites W2160654636 @default.
- W2563109049 cites W2161367595 @default.
- W2563109049 cites W2165877587 @default.
- W2563109049 cites W2268419391 @default.
- W2563109049 cites W2326819017 @default.
- W2563109049 cites W2327172638 @default.
- W2563109049 cites W2915142973 @default.
- W2563109049 cites W4210988559 @default.
- W2563109049 doi "https://doi.org/10.1016/j.jpba.2016.12.021" @default.
- W2563109049 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28033554" @default.
- W2563109049 hasPublicationYear "2017" @default.
- W2563109049 type Work @default.
- W2563109049 sameAs 2563109049 @default.
- W2563109049 citedByCount "23" @default.
- W2563109049 countsByYear W25631090492017 @default.
- W2563109049 countsByYear W25631090492018 @default.
- W2563109049 countsByYear W25631090492019 @default.
- W2563109049 countsByYear W25631090492020 @default.
- W2563109049 countsByYear W25631090492021 @default.
- W2563109049 countsByYear W25631090492022 @default.
- W2563109049 countsByYear W25631090492023 @default.
- W2563109049 crossrefType "journal-article" @default.
- W2563109049 hasAuthorship W2563109049A5004244292 @default.
- W2563109049 hasAuthorship W2563109049A5011674133 @default.
- W2563109049 hasAuthorship W2563109049A5035321872 @default.
- W2563109049 hasAuthorship W2563109049A5071773009 @default.
- W2563109049 hasAuthorship W2563109049A5075146505 @default.
- W2563109049 hasConcept C126322002 @default.
- W2563109049 hasConcept C185592680 @default.
- W2563109049 hasConcept C190409667 @default.
- W2563109049 hasConcept C2775900799 @default.
- W2563109049 hasConcept C2776279336 @default.
- W2563109049 hasConcept C2777756961 @default.
- W2563109049 hasConcept C2778163477 @default.
- W2563109049 hasConcept C2779399885 @default.
- W2563109049 hasConcept C2779701627 @default.
- W2563109049 hasConcept C2780480987 @default.
- W2563109049 hasConcept C2781089062 @default.
- W2563109049 hasConcept C2992208098 @default.
- W2563109049 hasConcept C515207424 @default.
- W2563109049 hasConcept C55493867 @default.
- W2563109049 hasConcept C71924100 @default.
- W2563109049 hasConcept C98274493 @default.
- W2563109049 hasConceptScore W2563109049C126322002 @default.
- W2563109049 hasConceptScore W2563109049C185592680 @default.
- W2563109049 hasConceptScore W2563109049C190409667 @default.
- W2563109049 hasConceptScore W2563109049C2775900799 @default.
- W2563109049 hasConceptScore W2563109049C2776279336 @default.