Matches in SemOpenAlex for { <https://semopenalex.org/work/W2563119588> ?p ?o ?g. }
- W2563119588 endingPage "401" @default.
- W2563119588 startingPage "396" @default.
- W2563119588 abstract "Exploration of the conformational spaces of flexible oligosaccharides is essential to gain deeper insights into their functional mechanisms. Here we characterised dynamic conformation of a high-mannose-type dodecasaccharide with a terminal glucose residue, a critical determinant recognised by molecular chaperones. The dodecasaccharide was prepared by our developed chemoenzymatic technique, which uses 13C labelling and lanthanide tagging to detect conformation-dependent paramagnetic effects by NMR spectroscopy. The NMR-validated molecular dynamics simulation produced the dynamic conformational ensemble of the dodecasaccharide. This determined its spatial distribution as well as the glycosidic linkage conformation of the terminal glucose determinant. Moreover, comparison of our results with previously reported crystallographic data indicates that the chaperone binding to its target oligosaccharides involves an induced-fit mechanism." @default.
- W2563119588 created "2017-01-06" @default.
- W2563119588 creator A5047494990 @default.
- W2563119588 creator A5052214706 @default.
- W2563119588 creator A5052818629 @default.
- W2563119588 creator A5062989683 @default.
- W2563119588 creator A5071010313 @default.
- W2563119588 creator A5075171995 @default.
- W2563119588 creator A5078685498 @default.
- W2563119588 creator A5081913243 @default.
- W2563119588 date "2017-01-04" @default.
- W2563119588 modified "2023-10-18" @default.
- W2563119588 title "Conformational Analysis of a High-Mannose-Type Oligosaccharide Displaying Glucosyl Determinant Recognised by Molecular Chaperones Using NMR-Validated Molecular Dynamics Simulation" @default.
- W2563119588 cites W165478984 @default.
- W2563119588 cites W1967126372 @default.
- W2563119588 cites W1977549744 @default.
- W2563119588 cites W1985986368 @default.
- W2563119588 cites W1986182839 @default.
- W2563119588 cites W1993144174 @default.
- W2563119588 cites W2017826436 @default.
- W2563119588 cites W2020224249 @default.
- W2563119588 cites W2036333455 @default.
- W2563119588 cites W2037875411 @default.
- W2563119588 cites W2038873242 @default.
- W2563119588 cites W2040545612 @default.
- W2563119588 cites W2040809566 @default.
- W2563119588 cites W2044217356 @default.
- W2563119588 cites W2049482681 @default.
- W2563119588 cites W2051227371 @default.
- W2563119588 cites W2061793634 @default.
- W2563119588 cites W2065681559 @default.
- W2563119588 cites W2067072165 @default.
- W2563119588 cites W2071548635 @default.
- W2563119588 cites W2071771346 @default.
- W2563119588 cites W2073062552 @default.
- W2563119588 cites W2086940592 @default.
- W2563119588 cites W2087512870 @default.
- W2563119588 cites W2092645001 @default.
- W2563119588 cites W2098943363 @default.
- W2563119588 cites W2100784701 @default.
- W2563119588 cites W2107572237 @default.
- W2563119588 cites W2118233996 @default.
- W2563119588 cites W2124800741 @default.
- W2563119588 cites W2151260212 @default.
- W2563119588 cites W2156619282 @default.
- W2563119588 cites W2171677744 @default.
- W2563119588 cites W2187079254 @default.
- W2563119588 cites W2949867270 @default.
- W2563119588 cites W4254149027 @default.
- W2563119588 cites W4256013443 @default.
- W2563119588 cites W561866174 @default.
- W2563119588 doi "https://doi.org/10.1002/cbic.201600595" @default.
- W2563119588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27995699" @default.
- W2563119588 hasPublicationYear "2017" @default.
- W2563119588 type Work @default.
- W2563119588 sameAs 2563119588 @default.
- W2563119588 citedByCount "24" @default.
- W2563119588 countsByYear W25631195882017 @default.
- W2563119588 countsByYear W25631195882018 @default.
- W2563119588 countsByYear W25631195882019 @default.
- W2563119588 countsByYear W25631195882020 @default.
- W2563119588 countsByYear W25631195882021 @default.
- W2563119588 countsByYear W25631195882022 @default.
- W2563119588 crossrefType "journal-article" @default.
- W2563119588 hasAuthorship W2563119588A5047494990 @default.
- W2563119588 hasAuthorship W2563119588A5052214706 @default.
- W2563119588 hasAuthorship W2563119588A5052818629 @default.
- W2563119588 hasAuthorship W2563119588A5062989683 @default.
- W2563119588 hasAuthorship W2563119588A5071010313 @default.
- W2563119588 hasAuthorship W2563119588A5075171995 @default.
- W2563119588 hasAuthorship W2563119588A5078685498 @default.
- W2563119588 hasAuthorship W2563119588A5081913243 @default.
- W2563119588 hasConcept C12554922 @default.
- W2563119588 hasConcept C142724271 @default.
- W2563119588 hasConcept C147597530 @default.
- W2563119588 hasConcept C150487720 @default.
- W2563119588 hasConcept C178910836 @default.
- W2563119588 hasConcept C181199279 @default.
- W2563119588 hasConcept C185592680 @default.
- W2563119588 hasConcept C2775887612 @default.
- W2563119588 hasConcept C2775962898 @default.
- W2563119588 hasConcept C2777726330 @default.
- W2563119588 hasConcept C2777936996 @default.
- W2563119588 hasConcept C55493867 @default.
- W2563119588 hasConcept C59593255 @default.
- W2563119588 hasConcept C66974803 @default.
- W2563119588 hasConcept C71240020 @default.
- W2563119588 hasConcept C71924100 @default.
- W2563119588 hasConcept C79156339 @default.
- W2563119588 hasConcept C86803240 @default.
- W2563119588 hasConceptScore W2563119588C12554922 @default.
- W2563119588 hasConceptScore W2563119588C142724271 @default.
- W2563119588 hasConceptScore W2563119588C147597530 @default.
- W2563119588 hasConceptScore W2563119588C150487720 @default.
- W2563119588 hasConceptScore W2563119588C178910836 @default.
- W2563119588 hasConceptScore W2563119588C181199279 @default.
- W2563119588 hasConceptScore W2563119588C185592680 @default.
- W2563119588 hasConceptScore W2563119588C2775887612 @default.