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- W2563134720 abstract "Background: Omalizumab has been introduced for treatment of severe steroid dependent asthma in Bulgaria since 2009. We analyzed its effectiveness in a patient population eligible for reimbursement according the National Health Insurance Fund criteria. Methods: We reviewed the records of all asthmatics put on omlizumab treatment through an established selection process in one of the 2 centers in the country. The variables included demographic data, disease and smoking history, spirometry, total IgE, blood eosinophils, success of treatment as judged by patients and doctors, discontinuation of systemic steroids, adverse events. Results: A total of 76 patients (52 women, 68%) on omalizumab had data from at least two visits 6 months apart. All were atopic with total IgE ranging from 81 to 1466 (median 302) IU/mL. Baseline FEV1 % predicted was 47.7%±5.8% [mean±s.e.m.] and blood eosinophils 410±48 cells/mcL. 13 patients (17%) discontinued treatment: 9 patients not experiencing subjective improvement, 3 patients having no effect as judged by their doctors, and 1 patient because of anaphylaxis. Binary logistic regression associated success of treatment positively with age and negatively with preceding asthma duration and pack years of smoking: odds ratio for success in relation to age was 1.065, 95% CI [1.004-1.130], P=0.04; to asthma duration 0.951 [0.904-1.001], P=0.05; to pack years 0.927 [0.864 -0.995], P=0.04. Conclusions: The majority (83%) of consecutive severe asthmatics on omalizumab in real-life patient population met the goals of treatment, with age as positive predictor of success; asthma duration and smoking were associated with the odds of failure." @default.
- W2563134720 created "2017-01-06" @default.
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- W2563134720 date "2015-09-01" @default.
- W2563134720 modified "2023-09-27" @default.
- W2563134720 title "Predictors of effectiveness of omalizumab treatment in patients with severe asthma recruited in a real-life setting" @default.
- W2563134720 doi "https://doi.org/10.1183/13993003.congress-2015.pa1018" @default.
- W2563134720 hasPublicationYear "2015" @default.
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