Matches in SemOpenAlex for { <https://semopenalex.org/work/W2563185004> ?p ?o ?g. }
- W2563185004 abstract "Specialized nucleoprotein structures, termed telomeres, cap the ends of human chromosomes. These terminal structures, composed of repetitive arrays of gua- nine-rich hexameric DNA together with specific telomere- binding proteins, play essential roles in protecting the chro- mosome from damage and degradation. In addition, several lines of evidence implicate telomere maintenance as an important regulator of cell life span. Activation of telom- erase, a dedicated reverse transcriptase that synthesizes telomeric sequences, is strongly associated with cancer, and recent observations confirm that telomeres and telomerase perform important roles in both suppressing and facilitating malignant transformation. These dual functions of telomere biology are evident in the clinical manifestations of the multisystem syndrome, dyskeratosis congenita, forms of which display defects in telomerase function. Recent ad- vances in our understanding of telomere biology indicate that the manipulation of telomeres and telomerase will lead to clinically significant applications in the diagnosis, preven- tion, and treatment of neoplastic disease. J Clin Oncol 21:2034-2043. © 2003 by American Society of Clinical Oncology." @default.
- W2563185004 created "2017-01-06" @default.
- W2563185004 creator A5063875415 @default.
- W2563185004 date "2003-01-01" @default.
- W2563185004 modified "2023-09-27" @default.
- W2563185004 title "Role o f T elomeres a nd T elomerase i n t he P athogenesis o f Human C ancer" @default.
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