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- W2563202234 abstract "A superparamagnetic iron oxide nanoparticles (SPIONs)/doxorubicin (Dox) co-loaded poly(lactic-co-glycolic acid) (PLGA)-based nanoparticles targeted with AS1411 aptamer (Apt) against murine C26 colon carcinoma cells is successfully developed via a modified multiple emulsion solvent evaporation method for theranostic purposes. The mean size of SPIO/Dox-NPs (NPs) was 130 nm with a narrow particle size distribution and Dox loading of 3.0%. The SPIO loading of 16.0% and acceptable magnetic properties are obtained and analyzed using thermogravimetric and vibration simple magnetometer analysis, respectively. The best release profile from NPs was observed in PBS at pH 7.4, in which very low burst release was observed. Nucleolin is a targeting ligand to facilitate anti-tumor delivery of AS1411-targeted NPs. The Apt conjugation to NPs (Apt-NPs) enhanced cellular uptake of Dox in C26 cancer cells. Apt-NPs enhance the cytotoxicity effect of Dox followed by a significantly higher tumor inhibition and prolonged animal survival in mice bearing C26 colon carcinoma xenografts. Furthermore, Apt-NPs enhance the contrast of magnetic resonance images in tumor site. Altogether, these Apt-NPs could be considered as a powerful tumor-targeted delivery system for their potential as dual therapeutic and diagnostic applications in cancers." @default.
- W2563202234 created "2017-01-06" @default.
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- W2563202234 date "2017-04-01" @default.
- W2563202234 modified "2023-10-01" @default.
- W2563202234 title "In vitro and in vivo evaluation of anti-nucleolin-targeted magnetic PLGA nanoparticles loaded with doxorubicin as a theranostic agent for enhanced targeted cancer imaging and therapy" @default.
- W2563202234 cites W1208915593 @default.
- W2563202234 cites W1533516721 @default.
- W2563202234 cites W1672714483 @default.
- W2563202234 cites W1892505945 @default.
- W2563202234 cites W1901595265 @default.
- W2563202234 cites W1925850732 @default.
- W2563202234 cites W1965077945 @default.
- W2563202234 cites W1968388237 @default.
- W2563202234 cites W1971380259 @default.
- W2563202234 cites W1975399536 @default.
- W2563202234 cites W1976505462 @default.
- W2563202234 cites W1976947090 @default.
- W2563202234 cites W1978940302 @default.
- W2563202234 cites W1984162012 @default.
- W2563202234 cites W1985944043 @default.
- W2563202234 cites W1986347816 @default.
- W2563202234 cites W1995009109 @default.
- W2563202234 cites W1996993122 @default.
- W2563202234 cites W2002948107 @default.
- W2563202234 cites W2003825254 @default.
- W2563202234 cites W2011030869 @default.
- W2563202234 cites W2013000677 @default.
- W2563202234 cites W2017402027 @default.
- W2563202234 cites W2017950444 @default.
- W2563202234 cites W2019555018 @default.
- W2563202234 cites W2020398834 @default.
- W2563202234 cites W2021347550 @default.
- W2563202234 cites W2027353500 @default.
- W2563202234 cites W2028816679 @default.
- W2563202234 cites W2032760352 @default.
- W2563202234 cites W2034735099 @default.
- W2563202234 cites W2036954929 @default.
- W2563202234 cites W2037571189 @default.
- W2563202234 cites W2038949845 @default.
- W2563202234 cites W2046480913 @default.
- W2563202234 cites W2046635748 @default.
- W2563202234 cites W2046851174 @default.
- W2563202234 cites W2048735112 @default.
- W2563202234 cites W2052606768 @default.
- W2563202234 cites W2053720633 @default.
- W2563202234 cites W2054745605 @default.
- W2563202234 cites W2055494875 @default.
- W2563202234 cites W2063553452 @default.
- W2563202234 cites W2064706547 @default.
- W2563202234 cites W2066685510 @default.
- W2563202234 cites W2070518196 @default.
- W2563202234 cites W2070932895 @default.
- W2563202234 cites W2072895628 @default.
- W2563202234 cites W2079109950 @default.
- W2563202234 cites W2080459218 @default.
- W2563202234 cites W2083710155 @default.
- W2563202234 cites W2086439640 @default.
- W2563202234 cites W2086637105 @default.
- W2563202234 cites W2088223764 @default.
- W2563202234 cites W2094141171 @default.
- W2563202234 cites W2100372768 @default.
- W2563202234 cites W2100892270 @default.
- W2563202234 cites W2102897174 @default.
- W2563202234 cites W2104496626 @default.
- W2563202234 cites W2106819793 @default.
- W2563202234 cites W2115072986 @default.
- W2563202234 cites W2129360146 @default.
- W2563202234 cites W2135384038 @default.
- W2563202234 cites W2137183456 @default.
- W2563202234 cites W2140502432 @default.
- W2563202234 cites W2142073291 @default.
- W2563202234 cites W2150433337 @default.
- W2563202234 cites W2154643481 @default.
- W2563202234 cites W2156694810 @default.
- W2563202234 cites W2159523065 @default.
- W2563202234 cites W2194137888 @default.
- W2563202234 doi "https://doi.org/10.1016/j.ejpb.2016.12.009" @default.
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