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• W2563220797 abstract "This chapter discusses the clinical pharmacology of the US Food and Drug Administration (FDA)-approved anticancer antibodies, processes, pharmacokinetics (PK) models and clinical parameters of monoclonal antibodies (mAb) PK, and the model and clinical data of mAb pharmacodynamics (PD). Pharmacological studies of anticancer mAb focus on the interaction between a patient population and the biopharmaceutical agent. PK is concerned with the biological processes that a drug undergoes in the intact organism, that is, what the body does to a drug. PD focuses on the therapeutic action of a drug on an organism, that is, pharmacologic response, as well as the duration and the magnitude of the response associated with the concentration of drug at an effectual site of the organism, in sum, what the body does to the drug. FDA has approved a number of therapeutic mAbs for anticancer treatment. Generally, the mAbs provide better clinical efficacy and/or fewer adverse side effects than conventional cancer therapy." @default.
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• W2563220797 date "2016-12-01" @default.
• W2563220797 modified "2023-09-27" @default.
• W2563220797 title "The Pharmacology, Pharmacokinetics, and Pharmacodynamics of Antibodies" @default.
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• W2563220797 doi "https://doi.org/10.1002/9781118940648.ch6" @default.
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