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• W2563258949 endingPage "322" @default.
• W2563258949 startingPage "322" @default.
• W2563258949 abstract "CD28 is a primary co-stimulatory receptor that is essential for successful T cell activation, proliferation, and survival. While ubiquitously expressed on naive T cells, the level of CD28 expression on memory T cells is largely dependent on the T-cell differentiation stage in humans. Expansion of circulating T cells lacking CD28 was originally considered a hallmark of age-associated immunological changes in humans, with a progressive loss of CD28 following replicative senescence with advancing age. However, an increasing body of evidence has revealed that there is a significant age-inappropriate expansion of CD4+CD28- T cells in patients with a variety of chronic inflammatory diseases, suggesting that these cells play a role in their pathogenesis. In fact, expanded CD4+CD28- T cells can produce large amounts of proinflammatory cytokines such as IFN-γ and TNF-α and also have cytotoxic potential, which may cause tissue damage and development of pathogenesis in many inflammatory disorders. Here we review the characteristics of CD4+CD28- T cells as well as the recent advances highlighting the contribution of these cells to several disease conditions." @default.
• W2563258949 created "2017-01-06" @default.
• W2563258949 creator A5061831347 @default.
• W2563258949 creator A5089953404 @default.
• W2563258949 date "2016-01-01" @default.
• W2563258949 modified "2023-10-15" @default.
• W2563258949 title "Unusual CD4⁺CD28⁻T Cells and Their Pathogenic Role in Chronic Inflammatory Disorders" @default.
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• W2563258949 doi "https://doi.org/10.4110/in.2016.16.6.322" @default.
• W2563258949 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5195841" @default.
• W2563258949 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28035207" @default.
• W2563258949 hasPublicationYear "2016" @default.
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