FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2563278350> ?p ?o ?g. }

• W2563278350 abstract "The commonest opioid used for pain relief in labour is pethidine (meperidine); however, its effectiveness has long been challenged and the drug has known side effects including maternal sedation, nausea and potential transfer across the placenta to the foetus. Over a third of women receiving pethidine require an epidural due to inadequate pain relief. Epidural analgesia increases the risk of an instrumental vaginal delivery and its associated effects. Therefore, there is a clear need for a safe, effective, alternative analgesic to pethidine. Evidence suggests that remifentanil patient-controlled analgesia (PCA) reduces epidural conversion rates compared to pethidine; however, no trial has yet investigated this as a primary endpoint. We are, therefore, comparing pethidine intramuscular injection to remifentanil PCA in a randomised controlled trial.Women in established labour, requesting systemic opioid pain relief, will be randomised to either intravenously administered remifentanil PCA (intervention) or pethidine intramuscular injection (control) in an unblinded, 1:1 individual randomised trial. Following informed consent, 400 women in established labour, who request systemic opioid pain relief, from NHS Trusts across England will undergo a minimised randomisation by a computer or automated telephone system to either pethidine or remifentanil. In order to balance the groups this minimisation is based on four parameters; parity (nulliparous versus multiparous), maternal age (<20, 20 < 30, 30 < 40, 40+ years), ethnicity (South Asian (Pakistani/Indian/Bangladeshi) versus Other) and induced versus spontaneous labour. The effectiveness of pain relief provided by each technique will be recorded every 30 min after time zero, until epidural placement, delivery or transfer to theatre, quantified by Visual Analogue Scale. Incidence of maternal side effects including sedation, delivery mode, foetal distress requiring delivery, neonatal status at delivery and rate of initiation of breastfeeding within the first hour of birth will also be recorded. Maternal satisfaction with her childbirth experience will be determined by a postpartum questionnaire prior to discharge from the delivery ward.The RESPITE trial's primary outcome is the proportion of women who have an epidural placed for pain relief in labour in each arm.Current Controlled Trials registration number: ISRCTN29654603 . Registered on 23 July 2013." @default.
• W2563278350 created "2017-01-06" @default.
• W2563278350 creator A5015023751 @default.
• W2563278350 creator A5019138306 @default.
• W2563278350 creator A5045595046 @default.
• W2563278350 creator A5070491005 @default.
• W2563278350 creator A5071206986 @default.
• W2563278350 creator A5085793081 @default.
• W2563278350 date "2016-12-01" @default.
• W2563278350 modified "2023-09-27" @default.
• W2563278350 title "The RESPITE trial: remifentanil intravenously administered patient-controlled analgesia (PCA) versus pethidine intramuscular injection for pain relief in labour: study protocol for a randomised controlled trial" @default.
• W2563278350 cites W1498235524 @default.
• W2563278350 cites W1559647774 @default.
• W2563278350 cites W1979467551 @default.
• W2563278350 cites W1982460292 @default.
• W2563278350 cites W1986801308 @default.
• W2563278350 cites W1991797729 @default.
• W2563278350 cites W1996751922 @default.
• W2563278350 cites W2003450728 @default.
• W2563278350 cites W2015775607 @default.
• W2563278350 cites W2037209955 @default.
• W2563278350 cites W2061476828 @default.
• W2563278350 cites W2075877650 @default.
• W2563278350 cites W2076878540 @default.
• W2563278350 cites W2080402977 @default.
• W2563278350 cites W2100116425 @default.
• W2563278350 cites W2103858265 @default.
• W2563278350 cites W2109953121 @default.
• W2563278350 cites W2125916573 @default.
• W2563278350 cites W2132839799 @default.
• W2563278350 cites W2137806753 @default.
• W2563278350 cites W2168851888 @default.
• W2563278350 doi "https://doi.org/10.1186/s13063-016-1708-3" @default.
• W2563278350 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5153689" @default.
• W2563278350 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27955688" @default.
• W2563278350 hasPublicationYear "2016" @default.
• W2563278350 type Work @default.
• W2563278350 sameAs 2563278350 @default.
• W2563278350 citedByCount "4" @default.
• W2563278350 countsByYear W25632783502018 @default.
• W2563278350 countsByYear W25632783502020 @default.
• W2563278350 countsByYear W25632783502021 @default.
• W2563278350 crossrefType "journal-article" @default.
• W2563278350 hasAuthorship W2563278350A5015023751 @default.
• W2563278350 hasAuthorship W2563278350A5019138306 @default.
• W2563278350 hasAuthorship W2563278350A5045595046 @default.
• W2563278350 hasAuthorship W2563278350A5070491005 @default.
• W2563278350 hasAuthorship W2563278350A5071206986 @default.
• W2563278350 hasAuthorship W2563278350A5085793081 @default.
• W2563278350 hasBestOaLocation W25632783501 @default.
• W2563278350 hasConcept C126322002 @default.
• W2563278350 hasConcept C141071460 @default.
• W2563278350 hasConcept C168563851 @default.
• W2563278350 hasConcept C170493617 @default.
• W2563278350 hasConcept C2776277131 @default.
• W2563278350 hasConcept C2778891214 @default.
• W2563278350 hasConcept C2779234561 @default.
• W2563278350 hasConcept C2779703513 @default.
• W2563278350 hasConcept C2780580376 @default.
• W2563278350 hasConcept C2780820201 @default.
• W2563278350 hasConcept C2781063702 @default.
• W2563278350 hasConcept C2781168792 @default.
• W2563278350 hasConcept C42219234 @default.
• W2563278350 hasConcept C54355233 @default.
• W2563278350 hasConcept C71924100 @default.
• W2563278350 hasConcept C86803240 @default.
• W2563278350 hasConceptScore W2563278350C126322002 @default.
• W2563278350 hasConceptScore W2563278350C141071460 @default.
• W2563278350 hasConceptScore W2563278350C168563851 @default.
• W2563278350 hasConceptScore W2563278350C170493617 @default.
• W2563278350 hasConceptScore W2563278350C2776277131 @default.
• W2563278350 hasConceptScore W2563278350C2778891214 @default.
• W2563278350 hasConceptScore W2563278350C2779234561 @default.
• W2563278350 hasConceptScore W2563278350C2779703513 @default.
• W2563278350 hasConceptScore W2563278350C2780580376 @default.
• W2563278350 hasConceptScore W2563278350C2780820201 @default.
• W2563278350 hasConceptScore W2563278350C2781063702 @default.
• W2563278350 hasConceptScore W2563278350C2781168792 @default.
• W2563278350 hasConceptScore W2563278350C42219234 @default.
• W2563278350 hasConceptScore W2563278350C54355233 @default.
• W2563278350 hasConceptScore W2563278350C71924100 @default.
• W2563278350 hasConceptScore W2563278350C86803240 @default.
• W2563278350 hasFunder F4320334659 @default.
• W2563278350 hasIssue "1" @default.
• W2563278350 hasLocation W25632783501 @default.
• W2563278350 hasLocation W25632783502 @default.
• W2563278350 hasLocation W25632783503 @default.
• W2563278350 hasLocation W25632783504 @default.
• W2563278350 hasLocation W25632783505 @default.
• W2563278350 hasLocation W25632783506 @default.
• W2563278350 hasOpenAccess W2563278350 @default.
• W2563278350 hasPrimaryLocation W25632783501 @default.
• W2563278350 hasRelatedWork W1898936260 @default.
• W2563278350 hasRelatedWork W2027686786 @default.
• W2563278350 hasRelatedWork W2037209955 @default.
• W2563278350 hasRelatedWork W2044449920 @default.
• W2563278350 hasRelatedWork W2096007971 @default.
• W2563278350 hasRelatedWork W2144507831 @default.
• W2563278350 hasRelatedWork W2164069434 @default.
• W2563278350 hasRelatedWork W2386876793 @default.

• next