FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2563295672> ?p ?o ?g. }

• W2563295672 endingPage "310" @default.
• W2563295672 startingPage "303" @default.
• W2563295672 abstract "Retinoic acid (RA) signaling is a central pathway regulating anterior-posterior patterning of the embryo through its targets, the Hox genes. RA is produced by two sequential oxidations from vitamin A (retinol) and this biosynthesis has to be regulated temporally, spatially and quantitatively. Mining Xenopus embryonic expression databases identified a novel component of the RA metabolic network, ADHFe1. Using Xenopus laevis embryos as our experimental system we determined the temporal and spatial pattern of AdhFe1 expression. Gain- and loss-of-function of ADHFe1 were induced to study its function and the regulation of the AdhFe1 gene by RA was studied. Expression analysis localized the ADHFe1 protein to the late Spemann’s organizer, the trunk organizer. Subsequently, ADHFe1 can be detected in the prechordal mesoderm, the notochord and the lateral plate mesoderm. Manipulation of ADHFe1 levels affects the normal Hox gene expression. The effects of ADHFe1 manipulation can by rescued by increasing the levels of RA or its biosynthesis. Expression of the AdhFe1 gene is regulated by RA itself. ADHFe1 is an enzyme active already during gastrula stages and the protein is still present during neurula stages. ADHFe1 regulates the expression of the Hox genes during the early patterning of the trunk. The effect of ADHFe1 on Hox expression is mediated through regulation of RA levels. ADHFe1 probably reduces retinaldehyde to retinol thereby restricting the availability of retinaldehyde, the substrate needed by retinaldehyde dehydrogenases to produce RA making it a novel regulator of RA concentrations in the embryo and RA homeostasis." @default.
• W2563295672 created "2017-01-06" @default.
• W2563295672 creator A5004229153 @default.
• W2563295672 creator A5053842570 @default.
• W2563295672 creator A5062215073 @default.
• W2563295672 date "2017-01-01" @default.
• W2563295672 modified "2023-10-16" @default.
• W2563295672 title "ADHFe1: a novel enzyme involved in retinoic acid-dependent Hox activation" @default.
• W2563295672 cites W1124269115 @default.
• W2563295672 cites W1527331090 @default.
• W2563295672 cites W1963660847 @default.
• W2563295672 cites W1965308726 @default.
• W2563295672 cites W1966968113 @default.
• W2563295672 cites W1975805528 @default.
• W2563295672 cites W1989127872 @default.
• W2563295672 cites W1998948010 @default.
• W2563295672 cites W1999488995 @default.
• W2563295672 cites W2002583871 @default.
• W2563295672 cites W2009866613 @default.
• W2563295672 cites W2010854221 @default.
• W2563295672 cites W2012601234 @default.
• W2563295672 cites W2021584737 @default.
• W2563295672 cites W2033588416 @default.
• W2563295672 cites W2057468741 @default.
• W2563295672 cites W2074448914 @default.
• W2563295672 cites W2075926808 @default.
• W2563295672 cites W2087296674 @default.
• W2563295672 cites W2097706568 @default.
• W2563295672 cites W2137668638 @default.
• W2563295672 cites W2139270152 @default.
• W2563295672 cites W2139841346 @default.
• W2563295672 cites W2157106675 @default.
• W2563295672 cites W2158050409 @default.
• W2563295672 cites W2303846091 @default.
• W2563295672 cites W2320950876 @default.
• W2563295672 cites W2327834369 @default.
• W2563295672 cites W2352023541 @default.
• W2563295672 cites W977588160 @default.
• W2563295672 doi "https://doi.org/10.1387/ijdb.160252af" @default.
• W2563295672 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28621427" @default.
• W2563295672 hasPublicationYear "2017" @default.
• W2563295672 type Work @default.
• W2563295672 sameAs 2563295672 @default.
• W2563295672 citedByCount "10" @default.
• W2563295672 countsByYear W25632956722018 @default.
• W2563295672 countsByYear W25632956722019 @default.
• W2563295672 countsByYear W25632956722020 @default.
• W2563295672 countsByYear W25632956722021 @default.
• W2563295672 countsByYear W25632956722022 @default.
• W2563295672 countsByYear W25632956722023 @default.
• W2563295672 crossrefType "journal-article" @default.
• W2563295672 hasAuthorship W2563295672A5004229153 @default.
• W2563295672 hasAuthorship W2563295672A5053842570 @default.
• W2563295672 hasAuthorship W2563295672A5062215073 @default.
• W2563295672 hasBestOaLocation W25632956721 @default.
• W2563295672 hasConcept C104317684 @default.
• W2563295672 hasConcept C111039654 @default.
• W2563295672 hasConcept C121587040 @default.
• W2563295672 hasConcept C129536746 @default.
• W2563295672 hasConcept C145103041 @default.
• W2563295672 hasConcept C150194340 @default.
• W2563295672 hasConcept C196843134 @default.
• W2563295672 hasConcept C2779535977 @default.
• W2563295672 hasConcept C2780172944 @default.
• W2563295672 hasConcept C2780915607 @default.
• W2563295672 hasConcept C2781121885 @default.
• W2563295672 hasConcept C54355233 @default.
• W2563295672 hasConcept C86803240 @default.
• W2563295672 hasConcept C87073359 @default.
• W2563295672 hasConcept C95444343 @default.
• W2563295672 hasConceptScore W2563295672C104317684 @default.
• W2563295672 hasConceptScore W2563295672C111039654 @default.
• W2563295672 hasConceptScore W2563295672C121587040 @default.
• W2563295672 hasConceptScore W2563295672C129536746 @default.
• W2563295672 hasConceptScore W2563295672C145103041 @default.
• W2563295672 hasConceptScore W2563295672C150194340 @default.
• W2563295672 hasConceptScore W2563295672C196843134 @default.
• W2563295672 hasConceptScore W2563295672C2779535977 @default.
• W2563295672 hasConceptScore W2563295672C2780172944 @default.
• W2563295672 hasConceptScore W2563295672C2780915607 @default.
• W2563295672 hasConceptScore W2563295672C2781121885 @default.
• W2563295672 hasConceptScore W2563295672C54355233 @default.
• W2563295672 hasConceptScore W2563295672C86803240 @default.
• W2563295672 hasConceptScore W2563295672C87073359 @default.
• W2563295672 hasConceptScore W2563295672C95444343 @default.
• W2563295672 hasIssue "3-4-5" @default.
• W2563295672 hasLocation W25632956721 @default.
• W2563295672 hasLocation W25632956722 @default.
• W2563295672 hasOpenAccess W2563295672 @default.
• W2563295672 hasPrimaryLocation W25632956721 @default.
• W2563295672 hasRelatedWork W1886964711 @default.
• W2563295672 hasRelatedWork W1965061371 @default.
• W2563295672 hasRelatedWork W2072631928 @default.
• W2563295672 hasRelatedWork W2092969708 @default.
• W2563295672 hasRelatedWork W2109479427 @default.
• W2563295672 hasRelatedWork W2147073510 @default.
• W2563295672 hasRelatedWork W2165080402 @default.
• W2563295672 hasRelatedWork W2169284834 @default.

• next