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- W2563412852 abstract "Background: It is common practice to pay more attention to the clearingof visible surface petroleum spills in streams and rivers which serveas the main source of drinking water in polluted sites in the NigerDelta area rather than taking cognizance of dissolved aromatichydrocarbons and metallic ions which are major components of petroleumproducts. For this reason, the toxicological effect of the watersoluble fraction (WSF) of Bonny light crude oil (BLCO) was evaluated.Methods: The range finding test was determined to be higher than 100%and showed no mortality or physical changes after 7 days. Wistar albinorats were exposed to three different concentrations (25, 50 and 100%)of WSF (BLCO) for a period of 28days. Results: Data from the studyshowed a significant (p≤0.05) increase in liver marker enzymes[aspartate amino transferase (AST), alanine amino transferase (ALT),alkaline phosphatase (ALP)] and biochemical parameters (cholesterol,urea, total and direct bilirubin) in rats exposed to WSF (BLCO).Generally, the increase in the level of biochemical parameters wasconcentration dependent with rats in the group treated with 100%concentration showing the highest activity when compared with control.There was a marginal decrease in the level of packed cell volume (PCV)and haemoglobin (Hb) in rats exposed to WSF (BLCO). White blood cell(WBC) of rats exposed to 25 and 50 % WSF (BLCO) increased marginallywhereas a significant (p≤ 0.05) increase was observed in thegroup exposed to 100% of WSF (BLCO). The histological examination ofrats exposed to different concentrations (25, 50 and 100%) of WSF(BLCO) were characterized by fatty change, inflammation of the cellwhereas rats in the control group showed normal architecture.Conclusion: The findings of this study highlights the deleterious andtoxicological effects of exposure to water polluted by dissolvedaromatic hydrocarbons probably present in WSF (BLCO)." @default.
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- W2563412852 date "2013-05-14" @default.
- W2563412852 modified "2023-09-23" @default.
- W2563412852 title "Hepatotoxicological evaluation of water-soluble fraction (WSF) of BonnyLight crude oil (BLCO) in Wistar albino rats" @default.
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