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- W2563514603 abstract "The use of self-organized multicellular spheroid cultures is particularly widespread in cancer biology, as changes in the cross talk between cells and the microenvironment are key to tumor initiation and progression. The option of fine-tuning microenvironmental parameters at the nanoscale should prove useful in unraveling their influence on cell functionality. Microfluidics allow for the spatiotemporal control over local chemical conditions at nanoscale precision. The integration of micro- and nanofabrication techniques with microfluidics provides exceptional opportunities to create structures of defined architecture and controlled environments. Microfluidic devices with controllable and flow-free reaction chambers can be also used for experiments on cell growth and organization in molecularly tunable environments. In particular, microfluidic systems hold great promise as an emerging tool for understanding cancer biology. Microfluidic cell culture systems are produced by microchip manufacturing methods. The microfluidic device was mounted on an inverted light microscope and three neighboring microchambers were monitored." @default.
- W2563514603 created "2017-01-06" @default.
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- W2563514603 date "2016-12-02" @default.
- W2563514603 modified "2023-10-17" @default.
- W2563514603 title "Self-Organization on a Chip: From Nanoscale Actin Assemblies to Tumor Spheroids" @default.
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- W2563514603 doi "https://doi.org/10.1002/9783527692057.ch10" @default.
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