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- W2563589900 abstract "Gracilariopsis chorda (Holmes) Ohmi is an edible perennial red alga in the family Gracilariaceae and is distributed in the coastal area of Gangneung, and Jeju islands in Korea [1]. Previous studies on G. chorda, have investigated anti-inflammatory activity and neuroprotective effects [2]. In continuation of our search for bioactive natural products, we have found that the EtOH extract of G. chorda has antihyperglycemic activity in the zebrafish model for type 1 diabetes, and anti-inflammatory activity. The zebrafish model for type 1 diabetes was induced by alloxan, which causes pancreatic β-cell necrosis [3]. The EtOH extract was consecutively partitioned with hexane, CH2Cl2, EtOAc and n-BuOH to give five fractions. Anti-diabetic activity of the solvent fractions was evaluated by using a zebrafish model. Following alloxan treatment, pancreatic islet size and fluorescence intensity were measured. Among the fractions, the CH2Cl2, n-BuOH and H2O fractions revealed potent anti-diabetic activity for type 1 at a concentration of100 µg/ml. We also evaluated the levels of inflammatory mediators in LPS-stimulated RAW 264.7 macrophages, and TNF-α-induced VCAM-1 expression in MOVAS-1 vascular smooth muscle cells. The hexane fraction and hexane and CH2Cl2 fractions significantly decreased IL-6 and TNF-α production, respectively. The VCAM-1 expression was inhibited significantly by hexane, CH2Cl2 and H2O fractions." @default.
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- W2563589900 date "2016-12-14" @default.
- W2563589900 modified "2023-09-26" @default.
- W2563589900 title "Anti-diabetic and anti-inflammatory activities of the edible red alga Gracilariopsis chorda" @default.
- W2563589900 doi "https://doi.org/10.1055/s-0036-1596663" @default.
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