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- W2563670182 abstract "• Epithelial cells have a polarized morphology, with distinct basal, lateral, and apical cell surfaces. It would be of considerable interest to know how the polarized morphology develops during embryogenesis. Both the tubular and glomerular epithelial cells of the kidney develop from mesenchymal stem cells during embryogenesis. A unique conversion of nonpolar cells to polarized epithelial cells thus occurs in the embryonic kidney. This conver sion also occurs in vitro if the mesenchymal cells are properly Induced. Organ cultures of mesenchymal cells from the mouse embryonic kidney have therefore been much used to study the development of epithelial cell polarity. We. have used this model system to study the role of basement membrane glycoprotelns In development. The results obtained suggest that lamlnins are particularly Important for epithelial cell development. There are many different types of lamlnlns. Developing kidney tubule cells synthesize a laminin isoform with the chain composi tion A-B1-B2, and It seems to promote development by Interacting with specific integrln receptors on the cell surface. The mesenchymal stem cells also produce lamlnln B chains, but not the A chain, and they also lack the integrin receptor that interacts with A-B1-B2 laminln. © 1991 by the National Kidney Foundation, Inc. INDEX WORDS: Laminin; basement membrane; integrins; cell polarity; kidney embryogenesis; organ culture." @default.
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- W2563670182 date "1991-01-01" @default.
- W2563670182 modified "2023-09-27" @default.
- W2563670182 title "ASPECTS OF RENAL GROWTH DURING FETAL AND NEONATAL DEVELOPMENT Laminin Isoforms and Their Receptors in the Developing Kidney" @default.
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