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- W2563670374 abstract "To determine if inflammatory marker and cytokine levels in maternal serum and cord blood are associated with fetal growth parameters in adolescent pregnancies. The trial was a prospective longitudinal cohort study of 158 pregnant adolescents ≤ 18 years of age assessing maternal and neonatal nutritional status. Adolescents with pre-existing medical complications were excluded from the study. Inflammatory markers (hepcidin and C-reactive protein (CRP)) and cytokines (IL-6, IL-10, TNF-α) were measured in archived serum collected at mid-gestation (mean 26 weeks), delivery (mean 38.8 weeks), and in umbilical cord blood. Sonographic fetal growth parameters were measured at three time points during pregnancy (mean 19.6, 26.6 and 34.5 weeks) and converted to z-scores based on gestational age. Newborn and placental growth were assessed after delivery. Linear regression models were used to determine if inflammatory markers and cytokines predict fetal growth. Multivariate linear regression was performed to evaluate the impact of potential confounding factors on the association between inflammatory markers and fetal growth. IL-6 in umbilical cord blood was positively associated with third trimester estimated fetal weight (p=0.026), abdominal circumference (p=0.049), fetal placental weight ratio (p=0.025) and newborn length-for-age (p=0.024). TNF-α in umbilical cord blood was positively associated with estimated fetal growth per week in the second and third trimesters (p=0.021). These findings remained statistically significant after adjusting for maternal age, weight, height, race and pregnancy weight gain. There was no association between fetal growth and maternal serum or cord blood levels of IL-10, CRP or hepcidin. Inflammatory cytokines (IL-6 and TNF-α) in cord blood, but not maternal serum, are significantly associated with increased fetal growth in adolescent pregnancies. This suggests a link between fetal inflammation and growth in this population." @default.
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- W2563670374 date "2017-01-01" @default.
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- W2563670374 title "778: Inflammatory cytokines in umbilical cord blood are associated with increased fetal growth in adolescent pregnancies" @default.
- W2563670374 doi "https://doi.org/10.1016/j.ajog.2016.11.511" @default.
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