Matches in SemOpenAlex for { <https://semopenalex.org/work/W2563705536> ?p ?o ?g. }
Showing items 1 to 85 of
85
with 100 items per page.
- W2563705536 abstract "Currently, vast amounts of molecular information involving genomic characterizations exist for various types of cancers. However, the integration of the various forms of biological data, necessary for a better understanding of the key processes underlying cancer, remains challenging. This project uses microarray based comparative genomic hybridization (aCGH) data to study genomic alterations on various tumor samples, with the statistical procedures in R. To find the hidden copy number states of each chromosome to characterize genomic alterations, this project utilizes Hidden Markov Models on datasets from cancer patients. The efficacy of the homogeneous and heterogeneous Hidden Markov Models is evaluated against the known truth of simulated data by looking at the true positive rates and false discovery rates for breakpoint detection. This project mainly determines the number and types of copy number variations present in the chromosomes of the tumor datasets, obtained from the The Cancer Genome Atlas portal. Recurrent chromosomal aberrations at particular genome locations may indicate the presence of tumor suppressor genes or oncogenes. After recognizing the chromosomes with high copy number changes, genes causing these high copy number variations are identified. The association between chromosomal location and cancer phenotype provides a more reliable and informative cancer genome characterization that can lead to useful insights into cancer biology for further disease classification, prognosis, and personalized treatment." @default.
- W2563705536 created "2017-01-06" @default.
- W2563705536 creator A5072108705 @default.
- W2563705536 date "2015-01-01" @default.
- W2563705536 modified "2023-09-27" @default.
- W2563705536 title "Systematic Analysis for Identification of Genes Impacting Cancers" @default.
- W2563705536 cites W1546952499 @default.
- W2563705536 cites W1608170587 @default.
- W2563705536 cites W2080920780 @default.
- W2563705536 cites W2082418604 @default.
- W2563705536 cites W2119317141 @default.
- W2563705536 cites W2125838338 @default.
- W2563705536 cites W2133174470 @default.
- W2563705536 cites W2155707112 @default.
- W2563705536 cites W2160697532 @default.
- W2563705536 cites W2168730720 @default.
- W2563705536 hasPublicationYear "2015" @default.
- W2563705536 type Work @default.
- W2563705536 sameAs 2563705536 @default.
- W2563705536 citedByCount "0" @default.
- W2563705536 crossrefType "journal-article" @default.
- W2563705536 hasAuthorship W2563705536A5072108705 @default.
- W2563705536 hasConcept C104317684 @default.
- W2563705536 hasConcept C116834253 @default.
- W2563705536 hasConcept C120821319 @default.
- W2563705536 hasConcept C121608353 @default.
- W2563705536 hasConcept C124942203 @default.
- W2563705536 hasConcept C141231307 @default.
- W2563705536 hasConcept C143425029 @default.
- W2563705536 hasConcept C166608930 @default.
- W2563705536 hasConcept C178169997 @default.
- W2563705536 hasConcept C189206191 @default.
- W2563705536 hasConcept C206936463 @default.
- W2563705536 hasConcept C30481170 @default.
- W2563705536 hasConcept C54355233 @default.
- W2563705536 hasConcept C552990157 @default.
- W2563705536 hasConcept C59822182 @default.
- W2563705536 hasConcept C70721500 @default.
- W2563705536 hasConcept C86803240 @default.
- W2563705536 hasConcept C99983632 @default.
- W2563705536 hasConceptScore W2563705536C104317684 @default.
- W2563705536 hasConceptScore W2563705536C116834253 @default.
- W2563705536 hasConceptScore W2563705536C120821319 @default.
- W2563705536 hasConceptScore W2563705536C121608353 @default.
- W2563705536 hasConceptScore W2563705536C124942203 @default.
- W2563705536 hasConceptScore W2563705536C141231307 @default.
- W2563705536 hasConceptScore W2563705536C143425029 @default.
- W2563705536 hasConceptScore W2563705536C166608930 @default.
- W2563705536 hasConceptScore W2563705536C178169997 @default.
- W2563705536 hasConceptScore W2563705536C189206191 @default.
- W2563705536 hasConceptScore W2563705536C206936463 @default.
- W2563705536 hasConceptScore W2563705536C30481170 @default.
- W2563705536 hasConceptScore W2563705536C54355233 @default.
- W2563705536 hasConceptScore W2563705536C552990157 @default.
- W2563705536 hasConceptScore W2563705536C59822182 @default.
- W2563705536 hasConceptScore W2563705536C70721500 @default.
- W2563705536 hasConceptScore W2563705536C86803240 @default.
- W2563705536 hasConceptScore W2563705536C99983632 @default.
- W2563705536 hasLocation W25637055361 @default.
- W2563705536 hasOpenAccess W2563705536 @default.
- W2563705536 hasPrimaryLocation W25637055361 @default.
- W2563705536 hasRelatedWork W1493356594 @default.
- W2563705536 hasRelatedWork W1968393646 @default.
- W2563705536 hasRelatedWork W1996442028 @default.
- W2563705536 hasRelatedWork W2045916345 @default.
- W2563705536 hasRelatedWork W2055336593 @default.
- W2563705536 hasRelatedWork W2101695910 @default.
- W2563705536 hasRelatedWork W2110313379 @default.
- W2563705536 hasRelatedWork W2114587116 @default.
- W2563705536 hasRelatedWork W2117968640 @default.
- W2563705536 hasRelatedWork W2121891923 @default.
- W2563705536 hasRelatedWork W2126486316 @default.
- W2563705536 hasRelatedWork W2137506169 @default.
- W2563705536 hasRelatedWork W2340542192 @default.
- W2563705536 hasRelatedWork W2411915702 @default.
- W2563705536 hasRelatedWork W2504851350 @default.
- W2563705536 hasRelatedWork W2758632382 @default.
- W2563705536 hasRelatedWork W2963159294 @default.
- W2563705536 hasRelatedWork W3048292987 @default.
- W2563705536 hasRelatedWork W3199638470 @default.
- W2563705536 hasRelatedWork W44413692 @default.
- W2563705536 isParatext "false" @default.
- W2563705536 isRetracted "false" @default.
- W2563705536 magId "2563705536" @default.
- W2563705536 workType "article" @default.