FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W256377588> ?p ?o ?g. }

• W256377588 endingPage "338" @default.
• W256377588 startingPage "335" @default.
• W256377588 abstract "In a previous communication (1) we reported the results of determinations oi the therapeutic effect of sulfonamide compounds in mice inoculated with Erysipelothrix rhusiopathiae. A report was also made of the ineffective use of these compounds in treatment of patients with erysipeloid of Rosenbach and in treatment of one patient with the septicemic form of the infection (2). In our experimental study sulfanilamide, sulfapyridine, sulfathiazole and sulfadiazine were separately administered to mice orally in doses of 0.2 Gm. per kilogram of body weight. To some the compounds were administered twice daily for two days before inoculation with a virulent strain of Erysipelothrix rhusiopathiae and twice daily thereafter for six additional days. For others treatment was begun four hours after inoculation and then administered twice daily for six additional days; in still others, for eight additional days. It was observed that 12.5 per cent of mice treated before or after the administration of these compounds survived. Additional evidence of some therapeutic effect was the greater percentage (50 per cent) of survival of the animals treated before inoculation and the longer time of survival of animals treated after inoculation compared with those of the untreated control group. The therapeutic effect of these compounds is therefore limited. Sulfanilamide and sulfapyridine appeared to give better results than sulfathiazole and sulfadiazine. The therapeutic effect of these compounds was slightly enhanced when they were employed in conjunction with subcurative injections of immune serum. In another communication (3) we studied the therapeutic effects of penicillin and streptomycin in mice inoculated with Erysipelothrix rhusiopathiae. In this study (3) the sodium salt of penicillin was administered in 5 daily injections for five successive days. The last of the daily injections (given in peanut oil-beeswax was twice the amount of the preceding four. The number of units per injection varied from 20 to 300. In some mice treatment was initiated immediately after inoculation, for others eight hours after inoculation, for still others sixteen hours after inoculation. The survival rate was 100 per cent with 600 units daily administered immediately after inoculation, and after treatment with 1,800 units daily beginning 8 hours after inoculation. The survival rate was 50 per cent after treatment with either 600 or 1200 units daily administered in 8 hours after inoculation. Streptomycin showed very slight therapeutic effect. Only four mice survived of 48 treated with varying numbers of units up to 3,600 units daily. The purpose of the present investigation was to determine if combined sul-" @default.
• W256377588 created "2016-06-24" @default.
• W256377588 creator A5036726936 @default.
• W256377588 creator A5052872151 @default.
• W256377588 date "1949-06-01" @default.
• W256377588 modified "2023-09-26" @default.
• W256377588 title "The Combined Effect of Sulfanilamide and Penicillin in Treatment of Experimental Erysipelothrix Rhusiopathiae Infection of Mice**From the Research Institute for Cutaneous Medicine. Philadelphia, Pa." @default.
• W256377588 cites W1975833125 @default.
• W256377588 cites W2052231401 @default.
• W256377588 cites W2061230578 @default.
• W256377588 cites W2069290695 @default.
• W256377588 cites W2095060305 @default.
• W256377588 cites W2418487616 @default.
• W256377588 doi "https://doi.org/10.1038/jid.1949.51" @default.
• W256377588 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/18150083" @default.
• W256377588 hasPublicationYear "1949" @default.
• W256377588 type Work @default.
• W256377588 sameAs 256377588 @default.
• W256377588 citedByCount "2" @default.
• W256377588 crossrefType "journal-article" @default.
• W256377588 hasAuthorship W256377588A5036726936 @default.
• W256377588 hasAuthorship W256377588A5052872151 @default.
• W256377588 hasBestOaLocation W2563775881 @default.
• W256377588 hasConcept C174802600 @default.
• W256377588 hasConcept C2778255925 @default.
• W256377588 hasConcept C2779056493 @default.
• W256377588 hasConcept C501593827 @default.
• W256377588 hasConcept C55493867 @default.
• W256377588 hasConcept C71924100 @default.
• W256377588 hasConcept C86803240 @default.
• W256377588 hasConcept C89423630 @default.
• W256377588 hasConceptScore W256377588C174802600 @default.
• W256377588 hasConceptScore W256377588C2778255925 @default.
• W256377588 hasConceptScore W256377588C2779056493 @default.
• W256377588 hasConceptScore W256377588C501593827 @default.
• W256377588 hasConceptScore W256377588C55493867 @default.
• W256377588 hasConceptScore W256377588C71924100 @default.
• W256377588 hasConceptScore W256377588C86803240 @default.
• W256377588 hasConceptScore W256377588C89423630 @default.
• W256377588 hasIssue "6" @default.
• W256377588 hasLocation W2563775881 @default.
• W256377588 hasLocation W2563775882 @default.
• W256377588 hasOpenAccess W256377588 @default.
• W256377588 hasPrimaryLocation W2563775881 @default.
• W256377588 hasRelatedWork W1970666145 @default.
• W256377588 hasRelatedWork W1995725751 @default.
• W256377588 hasRelatedWork W2001901738 @default.
• W256377588 hasRelatedWork W2057084417 @default.
• W256377588 hasRelatedWork W2089006325 @default.
• W256377588 hasRelatedWork W2099844172 @default.
• W256377588 hasRelatedWork W2123689798 @default.
• W256377588 hasRelatedWork W256377588 @default.
• W256377588 hasRelatedWork W4251655819 @default.
• W256377588 hasRelatedWork W4253507615 @default.
• W256377588 hasVolume "12" @default.
• W256377588 isParatext "false" @default.
• W256377588 isRetracted "false" @default.
• W256377588 magId "256377588" @default.
• W256377588 workType "article" @default.