Matches in SemOpenAlex for { <https://semopenalex.org/work/W2563780452> ?p ?o ?g. }
Showing items 1 to 74 of
74
with 100 items per page.
- W2563780452 endingPage "44" @default.
- W2563780452 startingPage "35" @default.
- W2563780452 abstract "The primary cilium which is an organelle in nearly every cell in the vertebrate body extends out of the cell surface like an antenna and is known as cell sensor of mechanical and chemical stimuli. In previous numerical simulations, researchers modeled this organelle as a cantilevered beam attached to the cell surface. In the present study, however, we present a novel model that accommodates for both pivoting and bending of primary cilium in response to the fluid flow. In this model, primary cilium is attached to the cell using a thin elastic layer. This layer, which comprises the bottom boundary of the cilium, provides the possibility of pivoting of the cilium around its base so that we are able to analyze the other part of ciliary response to the fluid flow. In this study, we have used finite element method and fluid-structure interaction techniques to simulate the problem. Domains of solid cilium and the surrounding fluid were meshed using triangular elements. The governing equations in this problem were fully coupled and were solved by the direct method. Graphs of maximum stress in the cilium base versus elastic constant of the thin layer depict two different trends. By scrutinizing colored plots of stress distribution in the cilium base it is construed that these trends represent two different mechanisms in ciliary deformation due to the flow of the fluid. In case of low elasticity constants, for which attachment of the cilium to the cell is soft, pivoting mechanism is essential, while in case of harder attachments, bending mechanism dominates." @default.
- W2563780452 created "2017-01-06" @default.
- W2563780452 creator A5041983705 @default.
- W2563780452 creator A5085909235 @default.
- W2563780452 date "2016-06-01" @default.
- W2563780452 modified "2023-09-23" @default.
- W2563780452 title "A finite elements study on the role of primary cilia in sensing mechanical stimuli to cells by calculating their response to the fluid flow" @default.
- W2563780452 doi "https://doi.org/10.22059/jcamech.2016.59253" @default.
- W2563780452 hasPublicationYear "2016" @default.
- W2563780452 type Work @default.
- W2563780452 sameAs 2563780452 @default.
- W2563780452 citedByCount "2" @default.
- W2563780452 countsByYear W25637804522019 @default.
- W2563780452 countsByYear W25637804522023 @default.
- W2563780452 crossrefType "journal-article" @default.
- W2563780452 hasAuthorship W2563780452A5041983705 @default.
- W2563780452 hasAuthorship W2563780452A5085909235 @default.
- W2563780452 hasConcept C100094513 @default.
- W2563780452 hasConcept C121332964 @default.
- W2563780452 hasConcept C135628077 @default.
- W2563780452 hasConcept C182310444 @default.
- W2563780452 hasConcept C2776983688 @default.
- W2563780452 hasConcept C2779126057 @default.
- W2563780452 hasConcept C38349280 @default.
- W2563780452 hasConcept C57879066 @default.
- W2563780452 hasConcept C62520636 @default.
- W2563780452 hasConcept C86803240 @default.
- W2563780452 hasConcept C90278072 @default.
- W2563780452 hasConcept C95444343 @default.
- W2563780452 hasConcept C97355855 @default.
- W2563780452 hasConceptScore W2563780452C100094513 @default.
- W2563780452 hasConceptScore W2563780452C121332964 @default.
- W2563780452 hasConceptScore W2563780452C135628077 @default.
- W2563780452 hasConceptScore W2563780452C182310444 @default.
- W2563780452 hasConceptScore W2563780452C2776983688 @default.
- W2563780452 hasConceptScore W2563780452C2779126057 @default.
- W2563780452 hasConceptScore W2563780452C38349280 @default.
- W2563780452 hasConceptScore W2563780452C57879066 @default.
- W2563780452 hasConceptScore W2563780452C62520636 @default.
- W2563780452 hasConceptScore W2563780452C86803240 @default.
- W2563780452 hasConceptScore W2563780452C90278072 @default.
- W2563780452 hasConceptScore W2563780452C95444343 @default.
- W2563780452 hasConceptScore W2563780452C97355855 @default.
- W2563780452 hasIssue "1" @default.
- W2563780452 hasLocation W25637804521 @default.
- W2563780452 hasOpenAccess W2563780452 @default.
- W2563780452 hasPrimaryLocation W25637804521 @default.
- W2563780452 hasRelatedWork W1974684276 @default.
- W2563780452 hasRelatedWork W1975182211 @default.
- W2563780452 hasRelatedWork W1977169393 @default.
- W2563780452 hasRelatedWork W1990001746 @default.
- W2563780452 hasRelatedWork W2000738274 @default.
- W2563780452 hasRelatedWork W2042813258 @default.
- W2563780452 hasRelatedWork W2043060213 @default.
- W2563780452 hasRelatedWork W2058706104 @default.
- W2563780452 hasRelatedWork W2078702456 @default.
- W2563780452 hasRelatedWork W2091559932 @default.
- W2563780452 hasRelatedWork W2106036549 @default.
- W2563780452 hasRelatedWork W2127312870 @default.
- W2563780452 hasRelatedWork W2167083105 @default.
- W2563780452 hasRelatedWork W2183211171 @default.
- W2563780452 hasRelatedWork W2289303461 @default.
- W2563780452 hasRelatedWork W2650301388 @default.
- W2563780452 hasRelatedWork W2781965088 @default.
- W2563780452 hasRelatedWork W3164412273 @default.
- W2563780452 hasRelatedWork W3185099703 @default.
- W2563780452 hasRelatedWork W3209852114 @default.
- W2563780452 hasVolume "47" @default.
- W2563780452 isParatext "false" @default.
- W2563780452 isRetracted "false" @default.
- W2563780452 magId "2563780452" @default.
- W2563780452 workType "article" @default.