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- W2563813226 abstract "e11101 Background: To assess the rate of chemotherapy-related complications in patients with metastatic breast cancer (mBC). Methods: Patients with mBC (including all biological subtypes) treated with chemotherapy and/or HER2-targeted agents were selected from the PharMetrics Integrated Database (2004-2009). Episodes of treatment (defined as a course of single-agent or combination) ≥30 days were identified. Rates of episodes associated with claims for complications were reported. Results: 1,551 patients (mean age 57±12]) with 3157 treatment episodes met the inclusion criteria. Out of the 3,157 treatment episodes, 1181 (37%) were combination regimens with 311 (26%) episodes of combination of chemotherapy with an anti-hormone agent. Patients had on average 2 episodes with a mean length of 131 days. The most frequently used agents were anti-HER2 (i.e., trastuzumab and lapatinib), docetaxel, paclitaxel, capecitabine, gemcitabine, vinorelbine, doxorubicin, bevacizumab, albumin-bound paclitaxel, and cyclophosphamide. Complication rates for the most common adverse events in regimens containing an anti-HER2 agent, docetaxel and paclitaxel are reported. Conclusions: The most frequent complications during an episode of mBC chemotherapy treatment were anemia, nausea/vomiting, bilirubin elevation, leukopenia, and infection. The impact of the high rates of these complications on treatment duration and compliance may lead to suboptimal clinical outcomes and higher costs. All episodes of treatment Anti-HER2-based regimen1 Docetaxel-based regimen2,3 Paclitaxel-based regimen2,3 Number of patients 1551 510 228 175 Number of episodes of treatment 3157 1157 264 188 Average by patient [median] 2.0 [2.0] 2.3 [2.0] 1.2 [1.0] 1.1 [1.0] Average duration (days) [median] 131 [91] 158 [104] 118 [88] 115 [78] Number of episodes with complications Anemia 51% 51% 55% 52% Bilirubin elevation 26% 29% 22% 31% Infection 19% 20% 23% 14% Leukopenia 25% 18% 36% 23% Nausea/vomiting 44% 41% 51% 45% 1Monotherapy or combination. 2Excluding HER2-agents. 3Monotherapy or combination with anti-hormone therapy." @default.
- W2563813226 created "2017-01-06" @default.
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- W2563813226 date "2011-05-20" @default.
- W2563813226 modified "2023-09-27" @default.
- W2563813226 title "Chemotherapy-related complication burden in patients with metastatic breast cancer in a real-world setting." @default.
- W2563813226 doi "https://doi.org/10.1200/jco.2011.29.15_suppl.e11101" @default.
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