FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2563934603> ?p ?o ?g. }

• W2563934603 abstract "Oncolytic virus has high potential for systemic cancer therapy because it does not require high initial intratumoral concentration for antitumor effect, and adenovirus (Ad) has been one of frequently-used platforms for oncolytic virus. However, its efficacy upon systemic application has been quite limited to date. Unlike loco-regional therapy, systemic application of cancer gene therapy mandates different level of selectivity of delivery, and lack of tumor selectivity at the stage of infection has hampered the in vivo efficacy of systemic therapy. The improvement of vector distribution and cancer selective transduction would overcome the obstacles for systemic delivery and enable efficient systemic treatment of cancer with oncolytic Ad.AdML-VTIN was identified as a mesothelin (MSLN) targeted Ad by high-throughput screening of Ad-fiber library. This AB-loop-redesigned Ad yielded a potent and selective infectivity to MSLN-positive pancreatic cancer (Panc-1) in vitro. Moreover, intra-tumor (i.t.) injection of AdML-VTIN (1010 vp/tumor) showed selective and powerful anti-tumor effect against Panc-1 tumors.In order to assess the potential of AdML-VTIN for systemic application, we compared organ distribution after intravenous (i.v.) injection to the nude mice with Panc-1 tumors between AdML-VTIN and AdML-5WT (wild type Ad5 fiber). The liver sequestration of AdML-VTIN was lowered more than one order of magnitude compared to AdML-5WT at both 1 hr and 48 hrs after injection. At day 7, the viral copy number of AdML-VTIN in the tumor was more than 3 orders of magnitude higher that those with AdML-5WT.Next, systemic therapeutic effect against Panc-1 tumors was compared with between AdML-VTIN and AdML-5WT with the low-dose single i.v. injection (109 vp/mouse). Tumor significantly shrunk only in AdML-VTIN treated group while AdML-5WT didn't show any growth suppression. Four out of ten tumors were eliminated at 15 days after the injection. Six out of ten AdML-VTIN treated tumors showed the regrowth, and these tumors were treated with multiple i.v. injections (day 47, 61, 68, and 75) of AdML-VTIN. Even though the multiple i.v. treatment was started after tumor volume reached 500 mm3, all mice survived until the end of experiment and four out of six regrown tumors showed remission. When therapeutic effect of AdML-VTIN was assessed with i.v. (systemic) and i.t. (local) injections, the tumor volume significant decreased in both groups. The anti-tumor effect of systemic i.v. injection group was similar to that of i.t. injection group at day 24 although the viral particle in the tumor with i.v. injection was about half of that with i.t. injection at day 1.In this study, systemic i.v. injection of the fiber-redesigned oncolytic Ad showed significantly lower liver sequestration and better tumor accumulation. More importantly, both systemic and intratumoral injections resulted in remarkable anti-tumor effect at low dose. An impressive anti-tumor effect of systemic administration indicated that targeted-oncolytic Ad may embody efficient treatment for cancers which are mostly found with spread or metastatic lesions." @default.
• W2563934603 created "2017-01-06" @default.
• W2563934603 creator A5015173376 @default.
• W2563934603 creator A5021602016 @default.
• W2563934603 creator A5040557156 @default.
• W2563934603 creator A5048788127 @default.
• W2563934603 date "2015-05-01" @default.
• W2563934603 modified "2023-09-23" @default.
• W2563934603 title "431. Efficient Systemic Treatment with Fiber-Redesigned Oncolytic Adenovirus in Pancreatic Cancer In Vivo Model" @default.
• W2563934603 doi "https://doi.org/10.1016/s1525-0016(16)34040-0" @default.
• W2563934603 hasPublicationYear "2015" @default.
• W2563934603 type Work @default.
• W2563934603 sameAs 2563934603 @default.
• W2563934603 citedByCount "0" @default.
• W2563934603 crossrefType "journal-article" @default.
• W2563934603 hasAuthorship W2563934603A5015173376 @default.
• W2563934603 hasAuthorship W2563934603A5021602016 @default.
• W2563934603 hasAuthorship W2563934603A5040557156 @default.
• W2563934603 hasAuthorship W2563934603A5048788127 @default.
• W2563934603 hasBestOaLocation W25639346031 @default.
• W2563934603 hasConcept C104317684 @default.
• W2563934603 hasConcept C111599444 @default.
• W2563934603 hasConcept C121608353 @default.
• W2563934603 hasConcept C126322002 @default.
• W2563934603 hasConcept C143998085 @default.
• W2563934603 hasConcept C150903083 @default.
• W2563934603 hasConcept C207001950 @default.
• W2563934603 hasConcept C25938499 @default.
• W2563934603 hasConcept C2777283488 @default.
• W2563934603 hasConcept C2780210213 @default.
• W2563934603 hasConcept C502942594 @default.
• W2563934603 hasConcept C55493867 @default.
• W2563934603 hasConcept C71924100 @default.
• W2563934603 hasConcept C82210918 @default.
• W2563934603 hasConcept C86803240 @default.
• W2563934603 hasConceptScore W2563934603C104317684 @default.
• W2563934603 hasConceptScore W2563934603C111599444 @default.
• W2563934603 hasConceptScore W2563934603C121608353 @default.
• W2563934603 hasConceptScore W2563934603C126322002 @default.
• W2563934603 hasConceptScore W2563934603C143998085 @default.
• W2563934603 hasConceptScore W2563934603C150903083 @default.
• W2563934603 hasConceptScore W2563934603C207001950 @default.
• W2563934603 hasConceptScore W2563934603C25938499 @default.
• W2563934603 hasConceptScore W2563934603C2777283488 @default.
• W2563934603 hasConceptScore W2563934603C2780210213 @default.
• W2563934603 hasConceptScore W2563934603C502942594 @default.
• W2563934603 hasConceptScore W2563934603C55493867 @default.
• W2563934603 hasConceptScore W2563934603C71924100 @default.
• W2563934603 hasConceptScore W2563934603C82210918 @default.
• W2563934603 hasConceptScore W2563934603C86803240 @default.
• W2563934603 hasLocation W25639346031 @default.
• W2563934603 hasOpenAccess W2563934603 @default.
• W2563934603 hasPrimaryLocation W25639346031 @default.
• W2563934603 hasRelatedWork W1506601197 @default.
• W2563934603 hasRelatedWork W1532473577 @default.
• W2563934603 hasRelatedWork W1971231025 @default.
• W2563934603 hasRelatedWork W2036906807 @default.
• W2563934603 hasRelatedWork W2057822452 @default.
• W2563934603 hasRelatedWork W2058190266 @default.
• W2563934603 hasRelatedWork W2068671045 @default.
• W2563934603 hasRelatedWork W2082629965 @default.
• W2563934603 hasRelatedWork W2152771990 @default.
• W2563934603 hasRelatedWork W2399473931 @default.
• W2563934603 hasRelatedWork W2561316018 @default.
• W2563934603 hasRelatedWork W2636701103 @default.
• W2563934603 hasRelatedWork W2740088187 @default.
• W2563934603 hasRelatedWork W2741817634 @default.
• W2563934603 hasRelatedWork W2948338093 @default.
• W2563934603 hasRelatedWork W2978740604 @default.
• W2563934603 hasRelatedWork W2989326204 @default.
• W2563934603 hasRelatedWork W3031514570 @default.
• W2563934603 hasRelatedWork W3101927444 @default.
• W2563934603 hasRelatedWork W2483361414 @default.
• W2563934603 isParatext "false" @default.
• W2563934603 isRetracted "false" @default.
• W2563934603 magId "2563934603" @default.
• W2563934603 workType "article" @default.