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• W2563958496 abstract "GABAergic interneurons play critical roles in seizures, but it remains unknown whether these vary across interneuron subtypes or evolve during a seizure. This uncertainty stems from the unpredictable timing of seizures in most models, which limits neuronal imaging or manipulations around the seizure onset. Here, we describe a mouse model for optogenetic seizure induction. Combining this with calcium imaging, we find that seizure onset rapidly recruits parvalbumin (PV), somatostatin (SOM), and vasoactive intestinal peptitde (VIP)-expressing interneurons, whereas excitatory neurons are recruited several seconds later. Optogenetically inhibiting VIP interneurons consistently increased seizure threshold and reduced seizure duration. Inhibiting PV+ and SOM+ interneurons had mixed effects on seizure initiation but consistently reduced seizure duration. Thus, while their roles may evolve during seizures, PV+ and SOM+ interneurons ultimately help maintain ongoing seizures. These results show how an optogenetically induced seizure model can be leveraged to pinpoint a new target for seizure control: VIP interneurons. VIDEO ABSTRACT." @default.
• W2563958496 created "2017-01-06" @default.
• W2563958496 creator A5025364268 @default.
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• W2563958496 date "2017-01-01" @default.
• W2563958496 modified "2023-10-12" @default.
• W2563958496 title "Dynamic, Cell-Type-Specific Roles for GABAergic Interneurons in a Mouse Model of Optogenetically Inducible Seizures" @default.
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• W2563958496 doi "https://doi.org/10.1016/j.neuron.2016.11.043" @default.
• W2563958496 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5268075" @default.
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