Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564089345> ?p ?o ?g. }
- W2564089345 abstract "By using tools from synthetic biology, sophisticated genetic devices can be assembled to reprogram mammalian cell activities. Here, we demonstrate that a self-adjusting synthetic gene circuit can be designed to sense and reverse the insulin-resistance syndrome in different mouse models. By functionally rewiring the mitogen-activated protein kinase (MAPK) signalling pathway to produce MAPK-mediated activation of the hybrid transcription factor TetR-ELK1, we assembled a synthetic insulin-sensitive transcription-control device that self-sufficiently distinguished between physiological and increased blood insulin levels and correspondingly fine-tuned the reversible expression of therapeutic transgenes from synthetic TetR-ELK1-specific promoters. In acute experimental hyperinsulinemia, the synthetic insulin-sensing designer circuit reversed the insulin-resistance syndrome by coordinating expression of the insulin-sensitizing compound adiponectin. Engineering synthetic gene circuits to sense pathologic markers and coordinate the expression of therapeutic transgenes may provide opportunities for future gene- and cell-based treatments of multifactorial metabolic disorders." @default.
- W2564089345 created "2017-01-06" @default.
- W2564089345 creator A5008369885 @default.
- W2564089345 creator A5016894108 @default.
- W2564089345 creator A5036357680 @default.
- W2564089345 creator A5036725778 @default.
- W2564089345 creator A5062976269 @default.
- W2564089345 creator A5069868537 @default.
- W2564089345 creator A5082252506 @default.
- W2564089345 date "2016-12-19" @default.
- W2564089345 modified "2023-10-15" @default.
- W2564089345 title "Self-adjusting synthetic gene circuit for correcting insulin resistance" @default.
- W2564089345 cites W1598254642 @default.
- W2564089345 cites W1645799104 @default.
- W2564089345 cites W1966291152 @default.
- W2564089345 cites W1994128751 @default.
- W2564089345 cites W2001052181 @default.
- W2564089345 cites W2004247546 @default.
- W2564089345 cites W2007620617 @default.
- W2564089345 cites W2013234054 @default.
- W2564089345 cites W2015244769 @default.
- W2564089345 cites W2019010829 @default.
- W2564089345 cites W2024102352 @default.
- W2564089345 cites W2036051969 @default.
- W2564089345 cites W2041272089 @default.
- W2564089345 cites W2041298130 @default.
- W2564089345 cites W2042352676 @default.
- W2564089345 cites W2044386584 @default.
- W2564089345 cites W2065700597 @default.
- W2564089345 cites W2085243036 @default.
- W2564089345 cites W2086102771 @default.
- W2564089345 cites W2087296862 @default.
- W2564089345 cites W2090029543 @default.
- W2564089345 cites W2102264538 @default.
- W2564089345 cites W2113464341 @default.
- W2564089345 cites W2115872041 @default.
- W2564089345 cites W2123907272 @default.
- W2564089345 cites W2129042241 @default.
- W2564089345 cites W2129816768 @default.
- W2564089345 cites W2132681327 @default.
- W2564089345 cites W2134293572 @default.
- W2564089345 cites W2137521058 @default.
- W2564089345 cites W2151656713 @default.
- W2564089345 cites W2155043929 @default.
- W2564089345 cites W2160234571 @default.
- W2564089345 cites W2160237938 @default.
- W2564089345 cites W2162250288 @default.
- W2564089345 cites W2165016692 @default.
- W2564089345 cites W2174637668 @default.
- W2564089345 cites W2278743348 @default.
- W2564089345 cites W2338167986 @default.
- W2564089345 cites W2345594933 @default.
- W2564089345 cites W644607308 @default.
- W2564089345 cites W999972457 @default.
- W2564089345 doi "https://doi.org/10.1038/s41551-016-0005" @default.
- W2564089345 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5412959" @default.
- W2564089345 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28480128" @default.
- W2564089345 hasPublicationYear "2016" @default.
- W2564089345 type Work @default.
- W2564089345 sameAs 2564089345 @default.
- W2564089345 citedByCount "77" @default.
- W2564089345 countsByYear W25640893452017 @default.
- W2564089345 countsByYear W25640893452018 @default.
- W2564089345 countsByYear W25640893452019 @default.
- W2564089345 countsByYear W25640893452020 @default.
- W2564089345 countsByYear W25640893452021 @default.
- W2564089345 countsByYear W25640893452022 @default.
- W2564089345 countsByYear W25640893452023 @default.
- W2564089345 crossrefType "journal-article" @default.
- W2564089345 hasAuthorship W2564089345A5008369885 @default.
- W2564089345 hasAuthorship W2564089345A5016894108 @default.
- W2564089345 hasAuthorship W2564089345A5036357680 @default.
- W2564089345 hasAuthorship W2564089345A5036725778 @default.
- W2564089345 hasAuthorship W2564089345A5062976269 @default.
- W2564089345 hasAuthorship W2564089345A5069868537 @default.
- W2564089345 hasAuthorship W2564089345A5082252506 @default.
- W2564089345 hasBestOaLocation W25640893452 @default.
- W2564089345 hasConcept C102230213 @default.
- W2564089345 hasConcept C104317684 @default.
- W2564089345 hasConcept C134018914 @default.
- W2564089345 hasConcept C150194340 @default.
- W2564089345 hasConcept C158448853 @default.
- W2564089345 hasConcept C184235292 @default.
- W2564089345 hasConcept C191908910 @default.
- W2564089345 hasConcept C2777274385 @default.
- W2564089345 hasConcept C2777391703 @default.
- W2564089345 hasConcept C2779306644 @default.
- W2564089345 hasConcept C54355233 @default.
- W2564089345 hasConcept C57074206 @default.
- W2564089345 hasConcept C70721500 @default.
- W2564089345 hasConcept C86803240 @default.
- W2564089345 hasConcept C95444343 @default.
- W2564089345 hasConceptScore W2564089345C102230213 @default.
- W2564089345 hasConceptScore W2564089345C104317684 @default.
- W2564089345 hasConceptScore W2564089345C134018914 @default.
- W2564089345 hasConceptScore W2564089345C150194340 @default.
- W2564089345 hasConceptScore W2564089345C158448853 @default.
- W2564089345 hasConceptScore W2564089345C184235292 @default.
- W2564089345 hasConceptScore W2564089345C191908910 @default.
- W2564089345 hasConceptScore W2564089345C2777274385 @default.