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- W2564132862 abstract "We report the use of bifunctional starting materials (ketoacids) in a diastereoselective Passerini three-center-two-component reaction. Study of the reaction scope revealed the required structural features for stereoselectivity in the isocyanide addition. In this system, an interesting isomerization of the primary Passerini product – the α-carboxamido lactone – into an atypical product, an α-hydroxy imide, was found to occur under acidic conditions. Furthermore, enantioenriched Passerini products can be generated from an enantioenriched ketoacid obtained by chemoenzymatic synthesis." @default.
- W2564132862 created "2017-01-06" @default.
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- W2564132862 date "2017-03-03" @default.
- W2564132862 modified "2023-10-18" @default.
- W2564132862 title "Stereoselective Synthesis of Functionalized Bicyclic Scaffolds by Passerini 3-Center-2-Component Reactions of Cyclic Ketoacids" @default.
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- W2564132862 doi "https://doi.org/10.1002/ejoc.201601432" @default.
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