Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564134166> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2564134166 abstract "Summary Recombinants with known gene constellations between fowl plague virus (FPV) and various prototype influenza virus strains have been examined for neurovirnlence in suckling mice. Strongly neurotropic recombinants were obtained from crosses between FPV and the strains virus N, Hong Kong, and Pl% 8, but not between FPV and cqui 2 or swine viruses. All highly neurotropic recombinants had RNA segment 4 (HA) derived from FPV and RNA segment 2 (Ptra gene) from the other prototype strain. The derivation of two other 1%NA segments of the polymerase complex, namely RNA segments 3 (Pol 2) and 5 (NP) and also segment 8 (NS) can modulate these properties. For example, if in recombinants between FPV and virus N in addition to RNA segment 2 also RNA segments 3 and/or 8 are derived from virus N, neurovirulence is further enhanced, while replacement of RNA segment 5 of FPV by the corresponding segment of virus N decreases or abolishes neurovirulence. The derivation of the other genes does not seem to be relevant for neurovirulence in the crosses mentioned above. Of the prototype strains tested, the turkey England (t. Engl.) strain is the only one which was highly neurotropic for suckling mice. l%ecombinants between FPV and t. Engl. which have kept the HA gene of t. Engl. were still nenrotropic, while those with the HA gene of FPV were completely avirulent. The results obtained demonstrated that 1. the creation of influenza virus recombinants neurotropic for mice is not a rare event; 2. one of the parents should multiply well in mouse lungs; 3. the presence of a cleavable hemagglutinin is necessary, but not sufficient. In the pair FPV/turkey England the hemagglutinin of turkey England seems to determine neurovirulence." @default.
- W2564134166 created "2017-01-06" @default.
- W2564134166 creator A5006913772 @default.
- W2564134166 creator A5024143059 @default.
- W2564134166 date "1983-01-01" @default.
- W2564134166 modified "2023-09-27" @default.
- W2564134166 title "Mouse Neurotropie Reeombinants of Influenza A Viruses" @default.
- W2564134166 cites W1484020396 @default.
- W2564134166 cites W1601512787 @default.
- W2564134166 cites W1732797741 @default.
- W2564134166 cites W1922042646 @default.
- W2564134166 cites W2034294969 @default.
- W2564134166 cites W2035643332 @default.
- W2564134166 cites W2041712815 @default.
- W2564134166 cites W2045670639 @default.
- W2564134166 cites W2065360819 @default.
- W2564134166 cites W2067126470 @default.
- W2564134166 cites W2068638130 @default.
- W2564134166 cites W2077407400 @default.
- W2564134166 cites W2090253529 @default.
- W2564134166 cites W2131208007 @default.
- W2564134166 hasPublicationYear "1983" @default.
- W2564134166 type Work @default.
- W2564134166 sameAs 2564134166 @default.
- W2564134166 citedByCount "0" @default.
- W2564134166 crossrefType "journal-article" @default.
- W2564134166 hasAuthorship W2564134166A5006913772 @default.
- W2564134166 hasAuthorship W2564134166A5024143059 @default.
- W2564134166 hasConcept C104317684 @default.
- W2564134166 hasConcept C105702510 @default.
- W2564134166 hasConcept C153911025 @default.
- W2564134166 hasConcept C159047783 @default.
- W2564134166 hasConcept C2522874641 @default.
- W2564134166 hasConcept C2778022156 @default.
- W2564134166 hasConcept C54355233 @default.
- W2564134166 hasConcept C67705224 @default.
- W2564134166 hasConcept C86803240 @default.
- W2564134166 hasConceptScore W2564134166C104317684 @default.
- W2564134166 hasConceptScore W2564134166C105702510 @default.
- W2564134166 hasConceptScore W2564134166C153911025 @default.
- W2564134166 hasConceptScore W2564134166C159047783 @default.
- W2564134166 hasConceptScore W2564134166C2522874641 @default.
- W2564134166 hasConceptScore W2564134166C2778022156 @default.
- W2564134166 hasConceptScore W2564134166C54355233 @default.
- W2564134166 hasConceptScore W2564134166C67705224 @default.
- W2564134166 hasConceptScore W2564134166C86803240 @default.
- W2564134166 hasLocation W25641341661 @default.
- W2564134166 hasOpenAccess W2564134166 @default.
- W2564134166 hasPrimaryLocation W25641341661 @default.
- W2564134166 hasRelatedWork W1593830213 @default.
- W2564134166 hasRelatedWork W1967753745 @default.
- W2564134166 hasRelatedWork W1976217594 @default.
- W2564134166 hasRelatedWork W2001445920 @default.
- W2564134166 hasRelatedWork W2016410818 @default.
- W2564134166 hasRelatedWork W2030119216 @default.
- W2564134166 hasRelatedWork W2035643332 @default.
- W2564134166 hasRelatedWork W2068638130 @default.
- W2564134166 hasRelatedWork W2069248741 @default.
- W2564134166 hasRelatedWork W2077407400 @default.
- W2564134166 hasRelatedWork W2087933112 @default.
- W2564134166 hasRelatedWork W2088538321 @default.
- W2564134166 hasRelatedWork W2093866615 @default.
- W2564134166 hasRelatedWork W2131208007 @default.
- W2564134166 hasRelatedWork W2154104745 @default.
- W2564134166 hasRelatedWork W2405820107 @default.
- W2564134166 hasRelatedWork W2414519266 @default.
- W2564134166 hasRelatedWork W2416692437 @default.
- W2564134166 hasRelatedWork W2418294644 @default.
- W2564134166 hasRelatedWork W2467565984 @default.
- W2564134166 isParatext "false" @default.
- W2564134166 isRetracted "false" @default.
- W2564134166 magId "2564134166" @default.
- W2564134166 workType "article" @default.