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- W2564138013 abstract "Two altered bovine growth hormone (bGH) genes (pBGH-M1 and pBGH-M8) were generated by use of oligonucleotide-directed mutagenesis protocols to determine the importance of an amphiphilic α-helix (helix three) in bGH relative to growth-related biological activities. pBGH-M1 encodes the changes of Lys-112 to Leu and Lys-114 to Trp and was designed to increase the hydrophobic region of the amphiphilic α-helix. pBGH-M8 encodes the changes of Glu-117 to Leu, Gly-119 to Arg, and Ala-122 to Asp and was designed to maximize the amphiphilicity of the helix. Both plasmids were expressed in mouse L cells. Transgenic mice that expressed pBGH-M1 showed a phenotype of enhanced growth typical of wild type bGH transgenic mice. However, transgenic mice that expressed pBGH-M8 demonstrated a growth-suppressed phenotype. The degree of growth suppression in the mice was directly related to serum levels of the altered bGH molecule." @default.
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- W2564138013 date "2000-01-01" @default.
- W2564138013 modified "2023-09-26" @default.
- W2564138013 title "Structure/function studies of the bovine growth hormone third α-helical region employing transgenic mice" @default.
- W2564138013 doi "https://doi.org/10.2527/2000.69suppl_338x" @default.
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