FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564161757> ?p ?o ?g. }

• W2564161757 endingPage "65" @default.
• W2564161757 startingPage "58" @default.
• W2564161757 abstract "Agastache mexicana has been used in traditional medicine for relief of abdominal pain and treatment of other diseases. Two subspecies have been identified: A. mexicana ssp. mexicana (AMM) and A. mexicana ssp. xolocotziana (AMX) and both are used traditionally without distinction or in combination. To determine the effect of methanol extracts of A. mexicana ssp. mexicana and A. mexicana ssp. xolocotziana on gut motility and their possible mechanism of action. The effect of AMM and AMX methanol extracts were tested on the spontaneous activity in the isolated guinea pig ileum and on tissues pre-contracted with KCl, electrical field stimulation (EFS) or ACh. In addition, the possible mechanism of action of each subspecies on gut motility was analyzed in the presence of hexametonium, indomethacin, L-NAME, verapamil, atropine or pyrylamine. A comparative chromatographic profile of these extracts was also done to indicate the most abundant flavonoids presents in methanol extracts of both subspecies. AMM, but not AMX, induced a contractile effect in the guinea pig ileum. This spasmogenic effect was partially inhibited by atropine, antagonist of muscarinic receptors; and pyrilamine, antagonist of H1 receptors. In contrast, AMX, but not AMM, diminished the contractions induced by KCl, EFS or ACh. The spasmolytic activity of AMX was partially inhibited by hexamethonium, ganglionic blocker; and indomethacin, inhibitor of the synthesis of prostaglandins; but not by L-NAME, inhibitor of nitric oxide synthase. In addition, AMX diminished the maximal contraction induced by CaCl2 in a calcium-free medium. Chromatographic analyses of these methanol extracts showed the presence of acacetin and tilanin in both. These results suggest that in folk medicine only AMX should be used as spasmolytic, and not in combination with AMM as traditionally occurs, due to the spasmogenic effects of the latter. In addition, activation of nicotinic receptors, prostaglandins and calcium channels, but not nitric oxide mechanisms, could be responsible for the spasmolytic activity of AMX. On the other hand, release of ACh and histamine could be involved in the spasmogenic effect induced by AMM. Acacetin and tilanin are present in methanol extracts of both subspecies and both flavonoids were more abundant in AMX than AMM. Our findings contribute to the validation of the traditional use of Agastache mexicana in relieving gastrointestinal disorders, but indicate that the subspecie that should be used for this effect is A. mexicana ssp. xolocotziana." @default.
• W2564161757 created "2017-01-06" @default.
• W2564161757 creator A5002002023 @default.
• W2564161757 creator A5012526517 @default.
• W2564161757 creator A5036192419 @default.
• W2564161757 creator A5046337208 @default.
• W2564161757 creator A5060135288 @default.
• W2564161757 creator A5064569759 @default.
• W2564161757 date "2017-01-01" @default.
• W2564161757 modified "2023-10-06" @default.
• W2564161757 title "Spasmogenic and spasmolytic activities of Agastache mexicana ssp. mexicana and A. mexicana ssp. xolocotziana methanolic extracts on the guinea pig ileum" @default.
• W2564161757 cites W119020515 @default.
• W2564161757 cites W1508399313 @default.
• W2564161757 cites W1596457615 @default.
• W2564161757 cites W1965001701 @default.
• W2564161757 cites W1971989349 @default.
• W2564161757 cites W1977709887 @default.
• W2564161757 cites W1986325598 @default.
• W2564161757 cites W1986920833 @default.
• W2564161757 cites W1989741102 @default.
• W2564161757 cites W1990722439 @default.
• W2564161757 cites W1995538444 @default.
• W2564161757 cites W1997687927 @default.
• W2564161757 cites W2008931162 @default.
• W2564161757 cites W2010679374 @default.
• W2564161757 cites W2016769131 @default.
• W2564161757 cites W2021514196 @default.
• W2564161757 cites W2024132287 @default.
• W2564161757 cites W2047418596 @default.
• W2564161757 cites W2049121118 @default.
• W2564161757 cites W2056040980 @default.
• W2564161757 cites W2060623507 @default.
• W2564161757 cites W2062197216 @default.
• W2564161757 cites W2069161855 @default.
• W2564161757 cites W2072981195 @default.
• W2564161757 cites W2075535804 @default.
• W2564161757 cites W2078400207 @default.
• W2564161757 cites W2089303572 @default.
• W2564161757 cites W2102551449 @default.
• W2564161757 cites W2112166832 @default.
• W2564161757 cites W2150231582 @default.
• W2564161757 cites W2264244090 @default.
• W2564161757 cites W4242976177 @default.
• W2564161757 doi "https://doi.org/10.1016/j.jep.2016.12.023" @default.
• W2564161757 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27988399" @default.
• W2564161757 hasPublicationYear "2017" @default.
• W2564161757 type Work @default.
• W2564161757 sameAs 2564161757 @default.
• W2564161757 citedByCount "15" @default.
• W2564161757 countsByYear W25641617572018 @default.
• W2564161757 countsByYear W25641617572019 @default.
• W2564161757 countsByYear W25641617572020 @default.
• W2564161757 countsByYear W25641617572021 @default.
• W2564161757 countsByYear W25641617572022 @default.
• W2564161757 countsByYear W25641617572023 @default.
• W2564161757 crossrefType "journal-article" @default.
• W2564161757 hasAuthorship W2564161757A5002002023 @default.
• W2564161757 hasAuthorship W2564161757A5012526517 @default.
• W2564161757 hasAuthorship W2564161757A5036192419 @default.
• W2564161757 hasAuthorship W2564161757A5046337208 @default.
• W2564161757 hasAuthorship W2564161757A5060135288 @default.
• W2564161757 hasAuthorship W2564161757A5064569759 @default.
• W2564161757 hasConcept C126322002 @default.
• W2564161757 hasConcept C134018914 @default.
• W2564161757 hasConcept C170493617 @default.
• W2564161757 hasConcept C185592680 @default.
• W2564161757 hasConcept C2775859210 @default.
• W2564161757 hasConcept C2776885963 @default.
• W2564161757 hasConcept C2777022698 @default.
• W2564161757 hasConcept C2777226302 @default.
• W2564161757 hasConcept C33789571 @default.
• W2564161757 hasConcept C519063684 @default.
• W2564161757 hasConcept C55493867 @default.
• W2564161757 hasConcept C71924100 @default.
• W2564161757 hasConcept C86803240 @default.
• W2564161757 hasConcept C98274493 @default.
• W2564161757 hasConceptScore W2564161757C126322002 @default.
• W2564161757 hasConceptScore W2564161757C134018914 @default.
• W2564161757 hasConceptScore W2564161757C170493617 @default.
• W2564161757 hasConceptScore W2564161757C185592680 @default.
• W2564161757 hasConceptScore W2564161757C2775859210 @default.
• W2564161757 hasConceptScore W2564161757C2776885963 @default.
• W2564161757 hasConceptScore W2564161757C2777022698 @default.
• W2564161757 hasConceptScore W2564161757C2777226302 @default.
• W2564161757 hasConceptScore W2564161757C33789571 @default.
• W2564161757 hasConceptScore W2564161757C519063684 @default.
• W2564161757 hasConceptScore W2564161757C55493867 @default.
• W2564161757 hasConceptScore W2564161757C71924100 @default.
• W2564161757 hasConceptScore W2564161757C86803240 @default.
• W2564161757 hasConceptScore W2564161757C98274493 @default.
• W2564161757 hasFunder F4320321739 @default.
• W2564161757 hasLocation W25641617571 @default.
• W2564161757 hasLocation W25641617572 @default.
• W2564161757 hasOpenAccess W2564161757 @default.
• W2564161757 hasPrimaryLocation W25641617571 @default.
• W2564161757 hasRelatedWork W1987061781 @default.
• W2564161757 hasRelatedWork W1987401576 @default.
• W2564161757 hasRelatedWork W2017036893 @default.

• next