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- W2564167788 abstract "The high per patient cost of quantitative, high-sensitivity molecular diagnostics is one of the key roadblocks limiting the transition of this technology from the clinical laboratory to point-of-care diagnostics in low-to-middle income countries (LMICs). As a solution, we present a low-cost system architecture for fluorescence-based point-of-care diagnostics using small volume patient sera samples. Our approach combines an inexpensive 4-site microscope slide reader with low per patient cost consumables using conventional glass microscope slides, pre-printed with biorecognition molecules. We use a neuromorphic-inspired, charge-integrating readout circuit architecture combined with optical filters in a sandwich-style configuration to achieve high-sensitivity while trading off detection time and number of biorecognition sites per slide. Our demonstrated lower limit of detection using Nile Red fluorescent microspheres was a 1,000,000:1 dilution corresponding to approximately 200 microspheres per detection site, approaching the sensitivity of a conventional high-cost desktop clinical laboratory microscope slide reader." @default.
- W2564167788 created "2017-01-06" @default.
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- W2564167788 date "2016-11-01" @default.
- W2564167788 modified "2023-09-26" @default.
- W2564167788 title "Low-cost, disposable fluorescence-based biorecognition system architecture for multiplexed point-of-care molecular diagnostics" @default.
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- W2564167788 doi "https://doi.org/10.1109/hic.2016.7797720" @default.
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