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- W2564172011 abstract "Abstract Pheomelanin is a sulphur‐containing yellow‐to‐reddish pigment whose synthesis consumes the main intracellular antioxidant (glutathione; GSH ) and its precursor cysteine. Cysteine used for pheomelanogenesis cannot be used for antioxidant protection. We tested whether the expression of Slc7a11 , the gene regulating the transport of cysteine to melanocytes for pheomelanogenesis, is environmentally influenced when cysteine/ GSH are most required for antioxidant protection. We found that zebra finches Taeniopygia guttata developing pheomelanin‐pigmented feathers during a 12‐day exposure to the pro‐oxidant diquat dibromide downregulated the expression of Slc7a11 in feather melanocytes, but not the expression of other genes that affect pheomelanogenesis by mechanisms different from cysteine transport such as MC 1R and Slc45a2 . Accordingly, diquat‐treated birds did not suffer increased oxidative stress. This indicates that some animals have evolved an adaptive epigenetic lability that avoids damage derived from pheomelanogenesis. This mechanism should be explored in human Slc7a11 to help combat some cancer types related to cysteine consumption." @default.
- W2564172011 created "2017-01-06" @default.
- W2564172011 creator A5043212403 @default.
- W2564172011 creator A5062829441 @default.
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- W2564172011 date "2017-01-31" @default.
- W2564172011 modified "2023-10-17" @default.
- W2564172011 title "Adaptive downregulation of pheomelanin-related <i>Slc7a11</i> gene expression by environmentally induced oxidative stress" @default.
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- W2564172011 doi "https://doi.org/10.1111/mec.13952" @default.
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