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• W2564206164 abstract "Background/Objectives . Obesity and metabolic syndrome and associated adiposity are a systemic condition characterized by increased mitochondrial dysfunction, inflammation, and inhibition of antioxidant genes, HO-1, and EETs levels. We postulate that EETs attenuate adiposity by stimulating mitochondrial function and induction of HO-1 via activation of PGC-1 α in adipose and hepatic tissue. Methods . Cultured murine adipocytes and mice fed a high fat (HF) diet were used to assess the functional relationship among EETs, PGC-1 α , HO-1, and mitochondrial signaling using an EET-agonist (EET-A) and PGC-1 α -deficient cells and mice using lentiviral PGC-1 α (sh). Results . EET-A is a potent inducer of PGC-1 α , HO-1, mitochondrial biogenesis (cytochrome oxidase subunits 1 and 4 and SIRT3), fusion proteins (Mfn<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M1><mml:mrow><mml:mrow><mml:mn fontstyle=italic>1</mml:mn></mml:mrow><mml:mo>/</mml:mo><mml:mrow><mml:mn fontstyle=italic>2</mml:mn></mml:mrow></mml:mrow></mml:math>and OPA1) and fission proteins (DRP1 and FIS1) (<mml:math xmlns:mml=http://www.w3.org/1998/Math/MathML id=M2><mml:mi>p</mml:mi><mml:mo><</mml:mo><mml:mn fontstyle=italic>0.05</mml:mn></mml:math>), fasting glucose, BW, and blood pressure. These beneficial effects were prevented by administration of lenti-PGC-1 α (sh). EET-A administration prevented HF diet induced mitochondrial and dysfunction in adipose tissue and restored VO 2 effects that were abrogated in PGC-1 α -deficient mice. Conclusion . EET is identified as an upstream positive regulator of PGC-1 α that leads to increased HO-1, decreased BW and fasting blood glucose and increased insulin receptor phosphorylation, that is, increased insulin sensitivity and mitochondrial integrity, and possible use of EET-agonist for treatment of obesity and metabolic syndrome." @default.
• W2564206164 created "2017-01-06" @default.
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• W2564206164 date "2016-01-01" @default.
• W2564206164 modified "2023-10-13" @default.
• W2564206164 title "Downregulation of PGC-1<i>α</i>Prevents the Beneficial Effect of EET-Heme Oxygenase-1 on Mitochondrial Integrity and Associated Metabolic Function in Obese Mice" @default.
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• W2564206164 doi "https://doi.org/10.1155/2016/9039754" @default.
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