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- W2564212320 abstract "Several studies have demonstrated an increase in follicular prostaglandin synthesis after gonadotrophic stimulation (LaMaire et al., 1973; Armstrong and Zamecnik, 1975). This synthesis and follicular rupture was inhibited by administration of indomethacin. The inhibitory action of indomethacin on follicular rupture was overcome by administration of PGE2 in rats (Tsafriri et al.,1972); PGF2a in rhesus monkeys (Wallach et al.,1975) and PGE2 or PGF2a in ewes (Murdoch et al.,1986). These fmdings led us to examine the role of a possible endogenous inhibitor of prostaglandin synthesis in bovine follicular fluid as well as changes in other regulatory factors. One of these regulatory factors is the tumor necrosis factor a (TNF), a protein produced by macrophages, which has been shown to participate in the regulation of cellular growth, macrophage prostaglandin synthesis and to alter follicular steroidogenesis in vitro." @default.
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- W2564212320 date "1990-01-01" @default.
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- W2564212320 title "TUMOR NECROSIS FACTOR (TNFa) AND THE ENDOGENOUS PROSTAGLANDIN INIllBITOR (pGIn) IN BOVINE FOLUCLES" @default.
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