FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564221105> ?p ?o ?g. }

• W2564221105 endingPage "81" @default.
• W2564221105 startingPage "72" @default.
• W2564221105 abstract "Bone resorption by osteoclasts (OCs) depends on the formation and stability of the sealing zone (SZ), a peripheral belt of actin and integrin-based podosomes. Recent studies demonstrated that the SZ is a highly dynamic structure, undergoing cycles of assembly and disassembly. In this study, we explored the mechanisms underlying the regulation of SZ stability and reorganization in OCs cultured on glass slides, and forming an SZ-like podosome belt (SZL). By monitoring this belt in cultured RAW264.7 cells expressing GFP-tagged actin, we show here that SZL stability is usually locally regulated, and its dissociation, occurring mostly in concave segments, is manifested in the loss of both podosome coherence, and actin belt continuity. Double labeling of cells for actin and tubulin indicated that microtubules (MTs) are mostly confined by the inner aspect of the stable SZL-associated actin belt. However, in unstable regions of the SZL, MTs tend to extend radially, across the SZL, toward the cell edge. Disruption of MTs by nocodazole induces SZ disassembly, without affecting individual podosome stability. Inspection of the MT network indicates that it is enriched along stable SZL regions, while bypassing disorganized regions. These results suggest that the SZL is stabilized by MTs flanking its inner aspect, while disruption or misalignment of MTs leads to SZL destabilization. We further demonstrate that the MT-associated protein dynamin2 is involved in the regulation of SZL stability, and dynamin2 knockdown or inactivation cause SZL destabilization." @default.
• W2564221105 created "2017-01-06" @default.
• W2564221105 creator A5003462136 @default.
• W2564221105 creator A5046264807 @default.
• W2564221105 creator A5055525128 @default.
• W2564221105 date "2017-02-01" @default.
• W2564221105 modified "2023-09-27" @default.
• W2564221105 title "Dynamics of the sealing zone in cultured osteoclasts" @default.
• W2564221105 cites W1526128150 @default.
• W2564221105 cites W1847131470 @default.
• W2564221105 cites W1890119853 @default.
• W2564221105 cites W1899740218 @default.
• W2564221105 cites W1908396212 @default.
• W2564221105 cites W1969894990 @default.
• W2564221105 cites W1974688989 @default.
• W2564221105 cites W1993006648 @default.
• W2564221105 cites W2005716633 @default.
• W2564221105 cites W2009996200 @default.
• W2564221105 cites W2027670444 @default.
• W2564221105 cites W2037574265 @default.
• W2564221105 cites W2039313004 @default.
• W2564221105 cites W2042808685 @default.
• W2564221105 cites W2047169413 @default.
• W2564221105 cites W2049939093 @default.
• W2564221105 cites W2051190059 @default.
• W2564221105 cites W2053911894 @default.
• W2564221105 cites W2054076584 @default.
• W2564221105 cites W2057649851 @default.
• W2564221105 cites W2081301424 @default.
• W2564221105 cites W2086531401 @default.
• W2564221105 cites W2103955782 @default.
• W2564221105 cites W2106516212 @default.
• W2564221105 cites W2111139783 @default.
• W2564221105 cites W2125644189 @default.
• W2564221105 cites W2130441255 @default.
• W2564221105 cites W2133161896 @default.
• W2564221105 cites W2141075109 @default.
• W2564221105 cites W2148153432 @default.
• W2564221105 cites W2151277678 @default.
• W2564221105 cites W2151891480 @default.
• W2564221105 cites W2157698908 @default.
• W2564221105 cites W2160623711 @default.
• W2564221105 cites W2165395398 @default.
• W2564221105 cites W2169061872 @default.
• W2564221105 cites W2203142910 @default.
• W2564221105 cites W2219311289 @default.
• W2564221105 cites W2286626550 @default.
• W2564221105 doi "https://doi.org/10.1002/cm.21350" @default.
• W2564221105 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5347972" @default.
• W2564221105 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27997747" @default.
• W2564221105 hasPublicationYear "2017" @default.
• W2564221105 type Work @default.
• W2564221105 sameAs 2564221105 @default.
• W2564221105 citedByCount "15" @default.
• W2564221105 countsByYear W25642211052018 @default.
• W2564221105 countsByYear W25642211052019 @default.
• W2564221105 countsByYear W25642211052020 @default.
• W2564221105 countsByYear W25642211052021 @default.
• W2564221105 countsByYear W25642211052022 @default.
• W2564221105 crossrefType "journal-article" @default.
• W2564221105 hasAuthorship W2564221105A5003462136 @default.
• W2564221105 hasAuthorship W2564221105A5046264807 @default.
• W2564221105 hasAuthorship W2564221105A5055525128 @default.
• W2564221105 hasBestOaLocation W25642211051 @default.
• W2564221105 hasConcept C12554922 @default.
• W2564221105 hasConcept C125705527 @default.
• W2564221105 hasConcept C141073059 @default.
• W2564221105 hasConcept C142669718 @default.
• W2564221105 hasConcept C1491633281 @default.
• W2564221105 hasConcept C20418707 @default.
• W2564221105 hasConcept C2779363559 @default.
• W2564221105 hasConcept C54355233 @default.
• W2564221105 hasConcept C86803240 @default.
• W2564221105 hasConcept C95444343 @default.
• W2564221105 hasConceptScore W2564221105C12554922 @default.
• W2564221105 hasConceptScore W2564221105C125705527 @default.
• W2564221105 hasConceptScore W2564221105C141073059 @default.
• W2564221105 hasConceptScore W2564221105C142669718 @default.
• W2564221105 hasConceptScore W2564221105C1491633281 @default.
• W2564221105 hasConceptScore W2564221105C20418707 @default.
• W2564221105 hasConceptScore W2564221105C2779363559 @default.
• W2564221105 hasConceptScore W2564221105C54355233 @default.
• W2564221105 hasConceptScore W2564221105C86803240 @default.
• W2564221105 hasConceptScore W2564221105C95444343 @default.
• W2564221105 hasIssue "2" @default.
• W2564221105 hasLocation W25642211051 @default.
• W2564221105 hasLocation W25642211052 @default.
• W2564221105 hasLocation W25642211053 @default.
• W2564221105 hasOpenAccess W2564221105 @default.
• W2564221105 hasPrimaryLocation W25642211051 @default.
• W2564221105 hasRelatedWork W2037078351 @default.
• W2564221105 hasRelatedWork W2039495782 @default.
• W2564221105 hasRelatedWork W2041091643 @default.
• W2564221105 hasRelatedWork W2069851853 @default.
• W2564221105 hasRelatedWork W2092808149 @default.
• W2564221105 hasRelatedWork W2113447040 @default.
• W2564221105 hasRelatedWork W2162546286 @default.
• W2564221105 hasRelatedWork W2427983053 @default.

• next