Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564236495> ?p ?o ?g. }
Showing items 1 to 95 of
95
with 100 items per page.
- W2564236495 endingPage "402" @default.
- W2564236495 startingPage "402" @default.
- W2564236495 abstract "402 Background: Altered cell cycle dynamics and check points are typical features of solid tumors, and cyclin dependent kinases (CDKs) play pivotal roles in these processes. Previously we have demonstrated that CDK-based analysis, composed of CDK1 and CDK2, is useful in the prediction of outcomes in early breast cancer patients (Ann Oncol. 19(1):68-72, 2008, Br J Cancer. 100(3):494-500, 2009). Clinically, there is a need for risk stratification in patients with stage II colon cancer who have a recurrence risk of 20 to 30%. Therefore we investigated the use of CDK-based analysis for recurrence prediction of stage II colon cancer patients. Methods: Fresh frozen tissue samples of 254 patients with histologically confirmed adenocarcinoma of the colon, UICC stage II, who received primary tumor resection in Munich (217 cases), and Leiden (37 cases) were used. Protein expression and activity of CDK1 and CDK2 were determined by in vitro assays as previously described. Specific activity (SA) of CDKs was calculated as kinase activity in relation to its corresponding mass concentration. Results: Development of distant metastasis was observed in 27 patients (10.6%) after a median follow up of 86 months. We found that predictive performance of CDK1SA, but not CDK2SA, for the metastasis was substantial and almost constant for long-term event prediction (average area under the curve (AUC) = 0.69). Tumor recurrence risk analysis in association with CDK1SA identified a low- (41% of population) and high- risk group (59%). Cox proportional hazard model analysis retained the CDK-based patient classification as an independent prognostic factor for distant metastases-free survival (low vs. high-risk group: Hazard ratio = 6.2, 95% CI: 1.45 to 26.9, p=0.0049). Clinical parameters such as grading, T-categories, age, and sex were excluded as confounding factors for CDK1SA-risk. Conclusions: CDK1SA allows stratification of different risk subgroups of stage II colon cancer patients. CDK1SA-based analysis is useful for predicting patients with high risk of distant recurrence, who should be treated with chemotherapy. No significant financial relationships to disclose." @default.
- W2564236495 created "2017-01-06" @default.
- W2564236495 creator A5005871829 @default.
- W2564236495 creator A5010136515 @default.
- W2564236495 creator A5031329882 @default.
- W2564236495 creator A5034543892 @default.
- W2564236495 creator A5044738843 @default.
- W2564236495 creator A5046341530 @default.
- W2564236495 creator A5052725166 @default.
- W2564236495 creator A5059606948 @default.
- W2564236495 creator A5079233267 @default.
- W2564236495 creator A5089608755 @default.
- W2564236495 date "2011-02-01" @default.
- W2564236495 modified "2023-09-25" @default.
- W2564236495 title "Specific activity of cyclin dependent kinase 1 as a novel predictor of recurrence risk in stage II colon cancer." @default.
- W2564236495 doi "https://doi.org/10.1200/jco.2011.29.4_suppl.402" @default.
- W2564236495 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27985763" @default.
- W2564236495 hasPublicationYear "2011" @default.
- W2564236495 type Work @default.
- W2564236495 sameAs 2564236495 @default.
- W2564236495 citedByCount "0" @default.
- W2564236495 crossrefType "journal-article" @default.
- W2564236495 hasAuthorship W2564236495A5005871829 @default.
- W2564236495 hasAuthorship W2564236495A5010136515 @default.
- W2564236495 hasAuthorship W2564236495A5031329882 @default.
- W2564236495 hasAuthorship W2564236495A5034543892 @default.
- W2564236495 hasAuthorship W2564236495A5044738843 @default.
- W2564236495 hasAuthorship W2564236495A5046341530 @default.
- W2564236495 hasAuthorship W2564236495A5052725166 @default.
- W2564236495 hasAuthorship W2564236495A5059606948 @default.
- W2564236495 hasAuthorship W2564236495A5079233267 @default.
- W2564236495 hasAuthorship W2564236495A5089608755 @default.
- W2564236495 hasConcept C120504264 @default.
- W2564236495 hasConcept C121608353 @default.
- W2564236495 hasConcept C124320809 @default.
- W2564236495 hasConcept C126322002 @default.
- W2564236495 hasConcept C143998085 @default.
- W2564236495 hasConcept C184235292 @default.
- W2564236495 hasConcept C203092338 @default.
- W2564236495 hasConcept C207103383 @default.
- W2564236495 hasConcept C2779013556 @default.
- W2564236495 hasConcept C2908647359 @default.
- W2564236495 hasConcept C29537977 @default.
- W2564236495 hasConcept C44249647 @default.
- W2564236495 hasConcept C50382708 @default.
- W2564236495 hasConcept C526805850 @default.
- W2564236495 hasConcept C535046627 @default.
- W2564236495 hasConcept C71924100 @default.
- W2564236495 hasConcept C82495950 @default.
- W2564236495 hasConcept C86803240 @default.
- W2564236495 hasConcept C90924648 @default.
- W2564236495 hasConcept C95444343 @default.
- W2564236495 hasConcept C99454951 @default.
- W2564236495 hasConceptScore W2564236495C120504264 @default.
- W2564236495 hasConceptScore W2564236495C121608353 @default.
- W2564236495 hasConceptScore W2564236495C124320809 @default.
- W2564236495 hasConceptScore W2564236495C126322002 @default.
- W2564236495 hasConceptScore W2564236495C143998085 @default.
- W2564236495 hasConceptScore W2564236495C184235292 @default.
- W2564236495 hasConceptScore W2564236495C203092338 @default.
- W2564236495 hasConceptScore W2564236495C207103383 @default.
- W2564236495 hasConceptScore W2564236495C2779013556 @default.
- W2564236495 hasConceptScore W2564236495C2908647359 @default.
- W2564236495 hasConceptScore W2564236495C29537977 @default.
- W2564236495 hasConceptScore W2564236495C44249647 @default.
- W2564236495 hasConceptScore W2564236495C50382708 @default.
- W2564236495 hasConceptScore W2564236495C526805850 @default.
- W2564236495 hasConceptScore W2564236495C535046627 @default.
- W2564236495 hasConceptScore W2564236495C71924100 @default.
- W2564236495 hasConceptScore W2564236495C82495950 @default.
- W2564236495 hasConceptScore W2564236495C86803240 @default.
- W2564236495 hasConceptScore W2564236495C90924648 @default.
- W2564236495 hasConceptScore W2564236495C95444343 @default.
- W2564236495 hasConceptScore W2564236495C99454951 @default.
- W2564236495 hasIssue "4_suppl" @default.
- W2564236495 hasLocation W25642364951 @default.
- W2564236495 hasOpenAccess W2564236495 @default.
- W2564236495 hasPrimaryLocation W25642364951 @default.
- W2564236495 hasRelatedWork W1919908042 @default.
- W2564236495 hasRelatedWork W2010115683 @default.
- W2564236495 hasRelatedWork W2038407368 @default.
- W2564236495 hasRelatedWork W2059374495 @default.
- W2564236495 hasRelatedWork W2065568989 @default.
- W2564236495 hasRelatedWork W2079096219 @default.
- W2564236495 hasRelatedWork W2084916586 @default.
- W2564236495 hasRelatedWork W2132726386 @default.
- W2564236495 hasRelatedWork W2331194212 @default.
- W2564236495 hasRelatedWork W2890048861 @default.
- W2564236495 hasVolume "29" @default.
- W2564236495 isParatext "false" @default.
- W2564236495 isRetracted "false" @default.
- W2564236495 magId "2564236495" @default.
- W2564236495 workType "article" @default.