FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2564255635> ?p ?o ?g. }

• W2564255635 abstract "In order to evaluate the role of persisting virus replication during occult phase immunisation in the live attenuated SIV vaccine model, a novel SIVmac239Δnef variant (SIVrtTA) genetically engineered to replicate in the presence of doxycycline was evaluated for its ability to protect against wild-type SIVmac239. Indian rhesus macaques were vaccinated either with SIVrtTA or with SIVmac239Δnef. Doxycycline was withdrawn from 4 of 8 SIVrtTA vaccinates before challenge with wild-type virus. Unvaccinated challenge controls exhibited ~107 peak plasma viral RNA copies/ml persisting beyond the acute phase. Six vaccinates, four SIVmac239Δnef and two SIVrtTA vaccinates exhibited complete protection, defined by lack of wild-type viraemia post-challenge and virus-specific PCR analysis of tissues recovered post-mortem, whereas six SIVrtTA vaccinates were protected from high levels of viraemia. Critically, the complete protection in two SIVrtTA vaccinates was associated with enhanced SIVrtTA replication in the immediate post-acute vaccination period but was independent of doxycycline status at the time of challenge. Mutations were identified in the LTR promoter region and rtTA gene that do not affect doxycycline-control but were associated with enhanced post-acute phase replication in protected vaccinates. High frequencies of total circulating CD8+T effector memory cells and a higher total frequency of SIV-specific CD8+ mono and polyfunctional T cells on the day of wild-type challenge were associated with complete protection but these parameters were not predictive of outcome when assessed 130 days after challenge. Moreover, challenge virus-specific Nef CD8+ polyfunctional T cell responses and antigen were detected in tissues post mortem in completely-protected macaques indicating post-challenge control of infection. Within the parameters of the study design, on-going occult-phase replication may not be absolutely required for protective immunity." @default.
• W2564255635 created "2017-01-06" @default.
• W2564255635 creator A5007774920 @default.
• W2564255635 creator A5013541619 @default.
• W2564255635 creator A5019287445 @default.
• W2564255635 creator A5020102382 @default.
• W2564255635 creator A5025335365 @default.
• W2564255635 creator A5025561786 @default.
• W2564255635 creator A5049681650 @default.
• W2564255635 creator A5050036080 @default.
• W2564255635 creator A5050659325 @default.
• W2564255635 creator A5057941992 @default.
• W2564255635 creator A5060410328 @default.
• W2564255635 creator A5071139482 @default.
• W2564255635 creator A5079154182 @default.
• W2564255635 date "2016-12-21" @default.
• W2564255635 modified "2023-09-24" @default.
• W2564255635 title "Role of Occult and Post-acute Phase Replication in Protective Immunity Induced with a Novel Live Attenuated SIV Vaccine" @default.
• W2564255635 cites W1545775398 @default.
• W2564255635 cites W1654759719 @default.
• W2564255635 cites W1833498951 @default.
• W2564255635 cites W1926245993 @default.
• W2564255635 cites W1964918056 @default.
• W2564255635 cites W1972984111 @default.
• W2564255635 cites W1980723592 @default.
• W2564255635 cites W1981785785 @default.
• W2564255635 cites W1999296717 @default.
• W2564255635 cites W1999786336 @default.
• W2564255635 cites W2009960465 @default.
• W2564255635 cites W2032428870 @default.
• W2564255635 cites W2034100391 @default.
• W2564255635 cites W2038735489 @default.
• W2564255635 cites W2066803746 @default.
• W2564255635 cites W2077348914 @default.
• W2564255635 cites W2078211589 @default.
• W2564255635 cites W2078936177 @default.
• W2564255635 cites W2083512827 @default.
• W2564255635 cites W2088253481 @default.
• W2564255635 cites W2088375515 @default.
• W2564255635 cites W209222179 @default.
• W2564255635 cites W2097849107 @default.
• W2564255635 cites W2101939402 @default.
• W2564255635 cites W2106777870 @default.
• W2564255635 cites W2125864180 @default.
• W2564255635 cites W2128772322 @default.
• W2564255635 cites W2129160854 @default.
• W2564255635 cites W2131743669 @default.
• W2564255635 cites W2134381509 @default.
• W2564255635 cites W2138165790 @default.
• W2564255635 cites W2140027694 @default.
• W2564255635 cites W2140893264 @default.
• W2564255635 cites W2156076060 @default.
• W2564255635 cites W2160719650 @default.
• W2564255635 cites W2162187516 @default.
• W2564255635 cites W2162863369 @default.
• W2564255635 cites W2165635529 @default.
• W2564255635 cites W2170278028 @default.
• W2564255635 cites W2170777857 @default.
• W2564255635 cites W2298434224 @default.
• W2564255635 cites W2321998793 @default.
• W2564255635 doi "https://doi.org/10.1371/journal.ppat.1006083" @default.
• W2564255635 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5176322" @default.
• W2564255635 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28002473" @default.
• W2564255635 hasPublicationYear "2016" @default.
• W2564255635 type Work @default.
• W2564255635 sameAs 2564255635 @default.
• W2564255635 citedByCount "6" @default.
• W2564255635 countsByYear W25642556352018 @default.
• W2564255635 countsByYear W25642556352019 @default.
• W2564255635 countsByYear W25642556352020 @default.
• W2564255635 countsByYear W25642556352021 @default.
• W2564255635 crossrefType "journal-article" @default.
• W2564255635 hasAuthorship W2564255635A5007774920 @default.
• W2564255635 hasAuthorship W2564255635A5013541619 @default.
• W2564255635 hasAuthorship W2564255635A5019287445 @default.
• W2564255635 hasAuthorship W2564255635A5020102382 @default.
• W2564255635 hasAuthorship W2564255635A5025335365 @default.
• W2564255635 hasAuthorship W2564255635A5025561786 @default.
• W2564255635 hasAuthorship W2564255635A5049681650 @default.
• W2564255635 hasAuthorship W2564255635A5050036080 @default.
• W2564255635 hasAuthorship W2564255635A5050659325 @default.
• W2564255635 hasAuthorship W2564255635A5057941992 @default.
• W2564255635 hasAuthorship W2564255635A5060410328 @default.
• W2564255635 hasAuthorship W2564255635A5071139482 @default.
• W2564255635 hasAuthorship W2564255635A5079154182 @default.
• W2564255635 hasBestOaLocation W25642556351 @default.
• W2564255635 hasConcept C104317684 @default.
• W2564255635 hasConcept C140704245 @default.
• W2564255635 hasConcept C159047783 @default.
• W2564255635 hasConcept C167672396 @default.
• W2564255635 hasConcept C203014093 @default.
• W2564255635 hasConcept C22070199 @default.
• W2564255635 hasConcept C2522874641 @default.
• W2564255635 hasConcept C2776185481 @default.
• W2564255635 hasConcept C2777179404 @default.
• W2564255635 hasConcept C2777995582 @default.
• W2564255635 hasConcept C2779341262 @default.
• W2564255635 hasConcept C501593827 @default.
• W2564255635 hasConcept C54355233 @default.
• W2564255635 hasConcept C54602769 @default.

• next